A new polyazomethine-based pyrazole moiety and its reinforced nanocomposites @ ZnO for antimicrobial applications.

IF 1.8 4区 化学 Q3 POLYMER SCIENCE
Designed Monomers and Polymers Pub Date : 2024-05-15 eCollection Date: 2024-01-01 DOI:10.1080/15685551.2024.2352897
Aqilah A Hakami, Hajar S Alorfi, Thoraya A Farghaly, Mahmoud A Hussein
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引用次数: 0

Abstract

A new class of biologically active polyazomethine/pyrazole and their related nanocomposites, polyazomethine/pyrazole/zinc oxide nanoparticles, have been successfully synthesized through the polycondensation technique in the form of polyazomethine pyrazole (PAZm/Py4-6) and polyazomethine/pyrazole/zinc oxide nanoparticles (PAZm/Py/ZnOa-c). The polymeric nanocomposites were prepared with a 5% loading of zinc oxide nanofiller using the same preparation technique, in addition to the help of ultrasonic radiation. The characteristics of the new polymers, such as solubility, viscometry, and molecular weight, were examined. All the polymers were completely soluble in the following solvents: concentrated sulfuric acid, formic acid, dimethylformamide, dimethyl sulfoxide, and tetrahydrofuran. Furthermore, the weight loss of the polyazomethine pyrazole (4, 5, and 6) at 800 °C was 67%, 95%, and 86%, respectively, which indicates the thermal stability of these polymers. At 800 °C, the polyazomethine/pyrazole/zinc oxide nanoparticles (a, b, and c) lost 74%, 68%, and 75% of their weight, respectively. This shows that adding zinc oxide nanoparticles made these compounds more stable at high temperatures. The X-Ray diffraction pattern of the polyazomethine pyrazole (PAZm/Py4-6) shows a number of sharp peaks with varying intensities. The polymers that were studied had straight crystal structures. Furthermore, the measurements of polyazomethine/pyrazole/zinc oxide nanoparticles (PAZm/Py/ZnOa-c) indicate a good merging of zinc oxide nanoparticles into the matrix of polymers. The antimicrobial activity of polymers and polymer nanocomposites was tested against some selected bacteria and fungi. The synthesized polymer (c) shows the highest activity against the two types of gram-negative bacteria selected. Most tested compounds were found to be effective against gram-positive bacteria except polyazomethine pyrazole (PAZm/Py5) and polyazomethine pyrazole (PAZm/Py6), which do not exhibit any activity. The synthesized polymers and their related nanocomposites were tested for their ability to kill the chosen fungi. All of them were effective against Aspergillus flavus, but only polyazomethine pyrazole (PAZm/Py4) and polyazomethine/pyrazole/zinc oxide (PAZm/Py/ZnOc) were effective against Candida albicans.

一种新型聚氮甲基吡唑分子及其增强纳米复合材料 @ ZnO 用于抗菌应用。
通过缩聚技术,成功合成了具有生物活性的新型聚氮甲胺/吡唑及其相关纳米复合材料--聚氮甲胺/吡唑/氧化锌纳米颗粒,即聚氮甲胺吡唑(PAZm/Py4-6)和聚氮甲胺/吡唑/氧化锌纳米颗粒(PAZm/Py/ZnOa-c)。使用相同的制备技术,并在超声波辐射的帮助下,制备了含有 5% 氧化锌纳米填料的聚合物纳米复合材料。对新聚合物的溶解度、粘度和分子量等特性进行了检测。所有聚合物都能完全溶于以下溶剂:浓硫酸、甲酸、二甲基甲酰胺、二甲亚砜和四氢呋喃。此外,聚氮甲基吡唑(4、5 和 6)在 800 ℃ 时的失重率分别为 67%、95% 和 86%,这表明了这些聚合物的热稳定性。800 °C 时,聚氮甲基吡唑/氧化锌纳米颗粒(a、b 和 c)的重量损失分别为 74%、68% 和 75%。这表明添加纳米氧化锌使这些化合物在高温下更加稳定。聚氮甲基吡唑(PAZm/Py4-6)的 X 射线衍射图样显示出一些强度不同的尖锐峰。所研究的聚合物具有平直的晶体结构。此外,聚氮甲基吡唑/氧化锌纳米颗粒(PAZm/Py/ZnOa-c)的测量结果表明,氧化锌纳米颗粒与聚合物基质的结合良好。测试了聚合物和聚合物纳米复合材料对一些特定细菌和真菌的抗菌活性。合成的聚合物 (c) 对所选的两种革兰氏阴性菌的活性最高。除了聚氮甲基吡唑(PAZm/Py5)和聚氮甲基吡唑(PAZm/Py6)没有表现出任何活性外,大多数测试化合物都对革兰氏阳性细菌有效。对合成的聚合物及其相关纳米复合材料杀死所选真菌的能力进行了测试。所有聚合物都对黄曲霉菌有效,但只有聚氮甲基吡唑(PAZm/Py4)和聚氮甲基/吡唑/氧化锌(PAZm/Py/ZnOc)对白色念珠菌有效。
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来源期刊
Designed Monomers and Polymers
Designed Monomers and Polymers 化学-高分子科学
CiteScore
3.30
自引率
0.00%
发文量
28
审稿时长
2.1 months
期刊介绍: Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work. The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications. DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to: -macromolecular science, initiators, macroinitiators for macromolecular design -kinetics, mechanism and modelling aspects of polymerization -new methods of synthesis of known monomers -new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization) -functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers -new polymeric materials with biomedical applications
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