Cigarette smoking and prostate cancer aggressiveness among African and European American men.

IF 2.2 4区 医学 Q3 ONCOLOGY
Cancer Causes & Control Pub Date : 2024-09-01 Epub Date: 2024-05-17 DOI:10.1007/s10552-024-01883-3
Edgar T Ellis, Brian J Fairman, Shelbie D Stahr, Jeannette T Bensen, James L Mohler, Lixin Song, Eboneé N Butler, L Joseph Su, Ping-Ching Hsu
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Abstract

Purpose: Smoking is a modifiable lifestyle factor that has not been established as a prostate cancer risk factor, nor emphasized in prostate cancer prevention. Studies have shown that African American (AA) smokers have a poorer cancer prognosis than European Americans (EAs), while having a lower prevalence of heavy smoking. We examined the relationship between cigarette smoking and prostate cancer aggressiveness and assessed racial differences in smoking habits on the probability of high-aggressive prostate cancer.

Methods: Using data from the North Carolina-Louisiana Prostate Cancer Project (n = 1,279), prostate cancer aggressiveness was defined as high or low based on Gleason scores, serum prostate-specific antigen levels, and tumor stage. Cigarette smoking was categorized as current, former, or never smokers. Multivariable logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI).

Results: Self-reported current (OR = 1.99; 95% CI 1.30-3.06) smoking was associated with high-aggressive prostate cancer relative to never smokers. When stratified by self-reported race, the odds of having high-aggressive cancer increased among AA current (OR = 3.58; 95% CI 2.04-6.28) and former smokers (OR = 2.21; 95% CI 1.38-3.53) compared to AA never smokers, but the odds were diminished among the EA stratum (Pself-reported race x smoking status = 0.003).

Conclusion: Cigarette smoking is associated with prostate cancer aggressiveness, a relationship modulated by self-reported race. Future research is needed to investigate types of cigarettes smoked and metabolic differences that may be contributing to the racial disparities observed.

非洲裔和欧洲裔美国男性吸烟与前列腺癌的侵袭性。
目的:吸烟是一种可改变的生活方式,但尚未被确定为前列腺癌的危险因素,也未在前列腺癌预防中得到重视。研究表明,非裔美国人(AA)吸烟者的癌症预后比欧裔美国人(EAs)差,但大量吸烟的发生率较低。我们研究了吸烟与前列腺癌侵袭性之间的关系,并评估了吸烟习惯的种族差异对高侵袭性前列腺癌概率的影响:利用北卡罗来纳州-路易斯安那州前列腺癌项目(n = 1,279)的数据,根据格里森评分、血清前列腺特异性抗原水平和肿瘤分期将前列腺癌侵袭性定义为高或低。吸烟者分为现在吸烟、曾经吸烟和从不吸烟。多变量逻辑回归用于估计调整后的几率比(OR)和95%置信区间(CI):结果:与从不吸烟者相比,自我报告的当前吸烟者(OR = 1.99; 95% CI 1.30-3.06)与高进展性前列腺癌相关。如果按自我报告的种族进行分层,与从不吸烟的 AA 族人相比,AA 族人中目前吸烟者(OR = 3.58;95% CI 2.04-6.28)和曾经吸烟者(OR = 2.21;95% CI 1.38-3.53)患高进展性癌症的几率增加,但 EA 族人中的几率降低(自我报告的种族 x 吸烟状况 = 0.003):结论:吸烟与前列腺癌的侵袭性有关,这种关系受自我报告的种族影响。未来的研究需要调查吸烟的类型以及可能导致种族差异的代谢差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cancer Causes & Control
Cancer Causes & Control 医学-公共卫生、环境卫生与职业卫生
CiteScore
3.90
自引率
4.30%
发文量
130
审稿时长
6.6 months
期刊介绍: Cancer Causes & Control is an international refereed journal that both reports and stimulates new avenues of investigation into the causes, control, and subsequent prevention of cancer. By drawing together related information published currently in a diverse range of biological and medical journals, it has a multidisciplinary and multinational approach. The scope of the journal includes: variation in cancer distribution within and between populations; factors associated with cancer risk; preventive and therapeutic interventions on a population scale; economic, demographic, and health-policy implications of cancer; and related methodological issues. The emphasis is on speed of publication. The journal will normally publish within 30 to 60 days of acceptance of manuscripts. Cancer Causes & Control publishes Original Articles, Reviews, Commentaries, Opinions, Short Communications and Letters to the Editor which will have direct relevance to researchers and practitioners working in epidemiology, medical statistics, cancer biology, health education, medical economics and related fields. The journal also contains significant information for government agencies concerned with cancer research, control and policy.
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