Electrochemical Sensors and Biosensors for Identification of Viruses: A Critical Review.

IF 4.2 2区 化学 Q1 CHEMISTRY, ANALYTICAL
Bozena Hosnedlova, Julia Werle, Jana Cepova, Vedha Hari B Narayanan, Lenka Vyslouzilova, Carlos Fernandez, Arli Aditya Parikesit, Marta Kepinska, Eva Klapkova, Karel Kotaska, Olga Stepankova, Geir Bjorklund, Richard Prusa, Rene Kizek
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Abstract

Due to their life cycle, viruses can disrupt the metabolism of their hosts, causing diseases. If we want to disrupt their life cycle, it is necessary to identify their presence. For this purpose, it is possible to use several molecular-biological and bioanalytical methods. The reference selection was performed based on electronic databases (2020-2023). This review focused on electrochemical methods with high sensitivity and selectivity (53% voltammetry/amperometry, 33% impedance, and 12% other methods) which showed their great potential for detecting various viruses. Moreover, the aforementioned electrochemical methods have considerable potential to be applicable for care-point use as they are portable due to their miniaturizability and fast speed analysis (minutes to hours), and are relatively easy to interpret. A total of 2011 articles were found, of which 86 original papers were subsequently evaluated (the majority of which are focused on human pathogens, whereas articles dealing with plant pathogens are in the minority). Thirty-two species of viruses were included in the evaluation. It was found that most of the examined research studies (77%) used nanotechnological modifications. Other ones performed immunological (52%) or genetic analyses (43%) for virus detection. 5% of the reports used peptides to increase the method's sensitivity. When evaluable, 65% of the research studies had LOD values in the order of ng or nM. The vast majority (79%) of the studies represent proof of concept and possibilities with low application potential and a high need of further research experimental work.

用于识别病毒的电化学传感器和生物传感器:批判性评论。
病毒的生命周期会破坏宿主的新陈代谢,从而引发疾病。如果我们想破坏病毒的生命周期,就必须确定病毒的存在。为此,可以使用多种分子生物学和生物分析方法。参考文献的选择基于电子数据库(2020-2023 年)。本综述侧重于具有高灵敏度和高选择性的电化学方法(伏安法/安培法占 53%,阻抗法占 33%,其他方法占 12%),这些方法在检测各种病毒方面具有巨大潜力。此外,上述电化学方法因其微型化和快速分析(数分钟至数小时)而便于携带,且相对易于解释,因此在护理点使用方面具有相当大的潜力。共找到 2011 篇文章,随后对其中的 86 篇原始论文进行了评估(其中大部分侧重于人类病原体,而涉及植物病原体的文章则占少数)。有 32 种病毒被纳入评估范围。结果发现,大部分受检研究(77%)使用了纳米技术修饰。其他研究则采用免疫分析(52%)或基因分析(43%)来检测病毒。5%的报告使用肽来提高方法的灵敏度。在可评估的情况下,65% 的研究报告的 LOD 值为 ng 或 nM。绝大多数研究(79%)都是概念验证和可能性研究,应用潜力较低,非常需要进一步的研究实验工作。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
12.00
自引率
4.00%
发文量
137
审稿时长
6 months
期刊介绍: Critical Reviews in Analytical Chemistry continues to be a dependable resource for both the expert and the student by providing in-depth, scholarly, insightful reviews of important topics within the discipline of analytical chemistry and related measurement sciences. The journal exclusively publishes review articles that illuminate the underlying science, that evaluate the field''s status by putting recent developments into proper perspective and context, and that speculate on possible future developments. A limited number of articles are of a "tutorial" format written by experts for scientists seeking introduction or clarification in a new area. This journal serves as a forum for linking various underlying components in broad and interdisciplinary means, while maintaining balance between applied and fundamental research. Topics we are interested in receiving reviews on are the following: · chemical analysis; · instrumentation; · chemometrics; · analytical biochemistry; · medicinal analysis; · forensics; · environmental sciences; · applied physics; · and material science.
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