Uptake of gadolinium and dexamethasone in rat inner ear and facial nerve using different administrations.

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

Acta Oto-Laryngologica Pub Date : 2024-03-01 Epub Date: 2024-05-16 DOI:10.1080/00016489.2024.2344807

Xing Jin, Yixu Wang, Liyuan Zhang, Hongwei Zheng, Xin Ma, Maoli Duan, Lisheng Yu

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引用次数: 0

Abstract

Background: The pathway by which drugs are injected subcutaneously behind the ear to act on the inner ear has not been fully elucidated.

Objectives: To compare the uptake of gadopentetate dimeglumine (Gd-DTPA) and dexamethasone (Dex) in the cochlea and facial nerve of rats following different administrations.

Materials and methods: Magnetic resonance imaging was applied to observe the distribution of Gd-DTPA in the facial nerve and inner ear. We observed the uptake of Dex after it was injected with different methods.

Results: Images of the intravenous (IV) and intramuscular (IM) groups showed that the bilateral cochlea of the rat was visualized almost simultaneously. While in the left post-auricular (PA) injection group, it was asynchronous. The maximum accumulation (C_max) of the Gd in the left facial nerve of the PA group (35.406 ± 5.32) was substantially higher than that of the IV group (16.765 ± 3.7542) (p < .01).

Conclusions: Compared with systemic administration, PA has the advantages of long Gd and Dex action time and high accumulation concentration to treat facial nerve diseases.

Significance: The distribution of Gd and Dex in the inner ear and facial nerve of rats following PA injection might be unique.

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大鼠内耳和面部神经对不同剂量钆和地塞米松的吸收。

背景：耳后皮下注射药物作用于内耳的途径尚未完全阐明：比较钆喷酸葡胺（Gd-DTPA）和地塞米松（Dex）在大鼠耳蜗和面神经中的摄取情况：应用磁共振成像技术观察 Gd-DTPA 在面神经和内耳中的分布。我们用不同的方法观察了大鼠注射 Dex 后的摄取情况：静脉注射组（IV）和肌肉注射组（IM）的图像显示，大鼠双侧耳蜗几乎同时显像。而左耳后（PA）注射组则不同步。PA 组（35.406 ± 5.32）的 Gd 在左侧面神经的最大蓄积量（Cmax）大大高于 IV 组（16.765 ± 3.7542）（p 结论：PA 组的 Gd 在左侧面神经的最大蓄积量（Cmax）大大高于 IV 组（p 结论：PA 组的 Gd 在左侧面神经的最大蓄积量（Cmax）大大高于 IV 组（p 结论：PA 组的 Gd 在左侧面神经的最大蓄积量（Cmax）大大高于 IV 组（p与全身给药相比，PA具有Gd和Dex作用时间长、蓄积浓度高的优点，可用于治疗面神经疾病：意义：注射 PA 后，Gd 和 Dex 在大鼠内耳和面神经中的分布可能是独特的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Oto-Laryngologica 医学-耳鼻喉科学

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

3-6 weeks

期刊介绍： Acta Oto-Laryngologica is a truly international journal for translational otolaryngology and head- and neck surgery. The journal presents cutting-edge papers on clinical practice, clinical research and basic sciences. Acta also bridges the gap between clinical and basic research.