(G)Patching up mis-splicing in cancer

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2024-07-01 DOI:10.1016/j.tibs.2024.05.001

Maciej Cieśla , Cristian Bellodi

引用次数: 0

Abstract

Benbarche, Pineda, Galvis, et al. delineate an essential role for the G-patch motif-containing protein GPATCH8 in mis-splicing associated with cancer-driving mutations of the splicing factor SF3B1. GPATCH8 cooperates with SF3B1 mutants, affecting the splicing machinery. Targeting GPATCH8 reveals therapeutic opportunities for SF3B1 mutant cancers and other splicing-related diseases.

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(G）修补癌症中的错误拼接。

Benbarche、Pineda、Galvis 等人发现，在与剪接因子 SF3B1 的癌症驱动突变相关的错误剪接中，含 G-补丁图案的蛋白质 GPATCH8 扮演着重要角色。 GPATCH8 与 SF3B1 突变体合作，影响剪接机制。针对 GPATCH8 的研究为 SF3B1 突变癌症和其他剪接相关疾病提供了治疗机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.