Neurocognitive functioning in adults with trichotillomania: Predictors of treatment response and symptom severity in a randomized control trial

IF 4.2 2区心理学 Q1 PSYCHOLOGY, CLINICAL

Behaviour Research and Therapy Pub Date : 2024-05-09 DOI:10.1016/j.brat.2024.104556

Kathryn E. Barber , Douglas W. Woods , Thilo Deckersbach , Christopher C. Bauer , Scott N. Compton , Michael P. Twohig , Emily J. Ricketts , Jordan Robinson , Stephen M. Saunders , Martin E. Franklin

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引用次数: 0

Abstract

Trichotillomania (TTM) is associated with impairments in response inhibition and cognitive flexibility, but it is unclear how such impairments relate to treatment outcome. The present study examined pre-treatment response inhibition and cognitive flexibility as predictors of treatment outcome, change in these domains from pre-to post-treatment, and associations with TTM severity. Participants were drawn from a randomized controlled trial comparing acceptance-enhanced behavior therapy (AEBT) to psychoeducation and supportive therapy (PST) for TTM. Adults completed assessments at pre-treatment (n = 88) and following 12 weeks of treatment (n = 68). Response inhibition and cognitive flexibility were assessed using the Stop Signal Task and Object Alternation Task, respectively. Participants completed the MGH-Hairpulling Scale. Independent evaluators administered the NIMH-Trichotillomania Severity Scale and Clinical Global Impressions-Improvement Scale. Higher pre-treatment TTM severity was associated with poorer pre-treatment cognitive flexibility, but not response inhibition. Better pre-treatment response inhibition performance predicted positive treatment response and lower post-treatment TTM symptom severity, irrespective of treatment assignment. Cognitive flexibility did not predict treatment response. After controlling for age, neither neurocognitive variable changed during treatment. Response inhibition and cognitive flexibility appear uniquely related to hair pulling severity and treatment response in adults with TTM. Implications for treatment delivery and development are discussed.

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成人毛手毛脚症患者的神经认知功能：随机对照试验中治疗反应和症状严重程度的预测因素

妄想症（TTM）与反应抑制和认知灵活性的损伤有关，但这种损伤与治疗结果的关系尚不清楚。本研究考察了作为治疗结果预测因素的治疗前反应抑制和认知灵活性、这些领域从治疗前到治疗后的变化以及与 TTM 严重程度的关联。参与者来自一项随机对照试验，该试验比较了接受增强行为疗法（AEBT）与心理教育和支持疗法（PST）对 TTM 的治疗效果。成人在治疗前（88 人）和治疗 12 周后（68 人）完成了评估。分别使用停止信号任务和物体交替任务对反应抑制和认知灵活性进行评估。参与者填写 MGH-拉头发量表。独立评估人员采用 NIMH-嗜眠症严重程度量表和临床总体印象-改善量表进行评估。治疗前 TTM 严重程度较高与治疗前认知灵活性较差有关，但与反应抑制能力无关。治疗前较好的反应抑制表现预示着积极的治疗反应和较低的治疗后TTM症状严重程度，与治疗分配无关。认知灵活性不能预测治疗反应。在控制了年龄之后，这两个神经认知变量在治疗过程中都没有发生变化。在患有 TTM 的成人中，反应抑制和认知灵活性似乎与拔毛严重程度和治疗反应有着独特的关系。本文讨论了治疗方法的提供和发展的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behaviour Research and Therapy PSYCHOLOGY, CLINICAL-

CiteScore

7.50

自引率

7.30%

发文量

148

期刊介绍： The major focus of Behaviour Research and Therapy is an experimental psychopathology approach to understanding emotional and behavioral disorders and their prevention and treatment, using cognitive, behavioral, and psychophysiological (including neural) methods and models. This includes laboratory-based experimental studies with healthy, at risk and subclinical individuals that inform clinical application as well as studies with clinically severe samples. The following types of submissions are encouraged: theoretical reviews of mechanisms that contribute to psychopathology and that offer new treatment targets; tests of novel, mechanistically focused psychological interventions, especially ones that include theory-driven or experimentally-derived predictors, moderators and mediators; and innovations in dissemination and implementation of evidence-based practices into clinical practice in psychology and associated fields, especially those that target underlying mechanisms or focus on novel approaches to treatment delivery. In addition to traditional psychological disorders, the scope of the journal includes behavioural medicine (e.g., chronic pain). The journal will not consider manuscripts dealing primarily with measurement, psychometric analyses, and personality assessment.