{"title":"Trait-anxiety and glial-related neuroinflammation of the amygdala and its associated regions in Alzheimer's disease: A significant correlation","authors":"Fumihiko Yasuno , Yasuyuki Kimura , Aya Ogata , Hiroshi Ikenuma , Junichiro Abe , Hiroyuki Minami , Takashi Nihashi , Kastunori Yokoi , Saori Hattori , Nobuyoshi Shimoda , Atsushi Watanabe , Kensaku Kasuga , Takeshi Ikeuchi , Akinori Takeda , Takashi Sakurai , Kengo Ito , Takashi Kato","doi":"10.1016/j.bbih.2024.100795","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Positron emission tomography, which assesses the binding of translocator protein radiotracers, <sup>11</sup>C-DPA-713, may be a sensitive method for determining glial-mediated neuroinflammation levels. This study investigated the relationship between regional <sup>11</sup>C-DPA713 binding potential (BP<sub>ND</sub>) and anxiety in patients with Alzheimer's disease (AD) continuum.</p></div><div><h3>Methods</h3><p>Nineteen patients with AD continuum determined to be amyloid-/p-tau 181-positive via cerebrospinal fluid analysis were included in this cross-sectional study (mild cognitive impairment [MCI, n = 5] and AD [n = 14]). Anxiety was evaluated using the State-Trait Anxiety Inventory (STAI). A whole-brain voxel-based analysis was performed to examine the relationship between <sup>11</sup>C-DPA-713-BP<sub>ND</sub> values at each voxel and the STAI score. Stepwise multiple regression analysis was performed to determine the predictors of STAI scores using independent variables, including <sup>11</sup>C-DPA-713-BP<sub>ND</sub> values within significant clusters. <sup>11</sup>C-DPA-713-BP<sub>ND</sub> values were compared between patients with AD continuum with low-to-moderate and high STAI scores.</p></div><div><h3>Results</h3><p>Voxel-based analysis revealed a positive correlation between trait anxiety severity and <sup>11</sup>C-DPA713-BP<sub>ND</sub> values in the centromedial amygdala and the left inferior occipital area [<em>P</em> < 0.001 (uncorrected) at the voxel-level]. <sup>11</sup>C-DPA713-BP<sub>ND</sub> values in these regions were a strong predictor of the STAI trait anxiety score. Specifically, patients with AD continuum and high trait anxiety had increased <sup>11</sup>C-DPA713-BP<sub>ND</sub> values in these regions.</p></div><div><h3>Conclusions</h3><p>The amygdala–occipital lobe circuit influences the control of emotional generation, and disruption of this network by AD pathology-induced inflammation may contribute to the expression of anxiety. Our findings suggest that suppression of inflammation can help effectively treat anxiety by attenuating damage to the amygdala and its associated areas.</p></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"38 ","pages":"Article 100795"},"PeriodicalIF":3.7000,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666354624000735/pdfft?md5=aef1dfda9e83d8bff04169208c9888b1&pid=1-s2.0-S2666354624000735-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain, behavior, & immunity - health","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666354624000735","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background
Positron emission tomography, which assesses the binding of translocator protein radiotracers, 11C-DPA-713, may be a sensitive method for determining glial-mediated neuroinflammation levels. This study investigated the relationship between regional 11C-DPA713 binding potential (BPND) and anxiety in patients with Alzheimer's disease (AD) continuum.
Methods
Nineteen patients with AD continuum determined to be amyloid-/p-tau 181-positive via cerebrospinal fluid analysis were included in this cross-sectional study (mild cognitive impairment [MCI, n = 5] and AD [n = 14]). Anxiety was evaluated using the State-Trait Anxiety Inventory (STAI). A whole-brain voxel-based analysis was performed to examine the relationship between 11C-DPA-713-BPND values at each voxel and the STAI score. Stepwise multiple regression analysis was performed to determine the predictors of STAI scores using independent variables, including 11C-DPA-713-BPND values within significant clusters. 11C-DPA-713-BPND values were compared between patients with AD continuum with low-to-moderate and high STAI scores.
Results
Voxel-based analysis revealed a positive correlation between trait anxiety severity and 11C-DPA713-BPND values in the centromedial amygdala and the left inferior occipital area [P < 0.001 (uncorrected) at the voxel-level]. 11C-DPA713-BPND values in these regions were a strong predictor of the STAI trait anxiety score. Specifically, patients with AD continuum and high trait anxiety had increased 11C-DPA713-BPND values in these regions.
Conclusions
The amygdala–occipital lobe circuit influences the control of emotional generation, and disruption of this network by AD pathology-induced inflammation may contribute to the expression of anxiety. Our findings suggest that suppression of inflammation can help effectively treat anxiety by attenuating damage to the amygdala and its associated areas.
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