Sex considerations in regenerative rehabilitation strategies for the treatment of knee osteoarthritis

IF 4.7 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL
Hirotaka Iijima , Ryo Nakahara , Akira Ito
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Abstract

Regenerative rehabilitation is a promising field aimed at harnessing the regenerative potential of stem-cell therapeutics to maximize functional recovery. Here, we outline recent advancements in the field of regenerative rehabilitation for treating knee osteoarthritis (KOA) and we highlight sex-specific considerations to promote knowledge translation to the clinic. A systematic review suggests that sexual dimorphism in the efficacy of regenerative rehabilitation approaches for the treatment of KOA may be partly attributed to the functional decline of female mesenchymal stem cells (MSCs) over the lifespan, particularly after menopause. These declines are likely to be accompanied by poor clinical outcomes. While evidence is far from adequate, physical therapeutics have emerged as a means to promote estrogen signaling in MSCs, potentially reversing menopause-related MSC dysfunction. This study calls for actions to dissect the effects of menopause, together with physical therapeutics, on stem-cell therapeutics toward the development of effective regenerative rehabilitation approaches.

Abstract Image

治疗膝关节骨性关节炎的再生康复策略中的性别考虑因素
再生康复是一个前景广阔的领域,旨在利用干细胞疗法的再生潜力,最大限度地恢复功能。在此,我们概述了再生康复治疗膝关节骨性关节炎(KOA)领域的最新进展,并强调了促进临床知识转化的性别特异性考虑因素。一项系统性综述表明,治疗膝骨关节炎的再生康复方法在疗效上的性别双态性可能部分归因于女性间充质干细胞(MSCs)在生命周期中的功能衰退,尤其是在绝经后。这些衰退很可能伴随着不良的临床结果。虽然证据远远不够充分,但物理疗法已成为促进间充质干细胞雌激素信号转导的一种手段,有可能逆转与更年期有关的间充质干细胞功能障碍。这项研究呼吁采取行动,剖析更年期和物理治疗对干细胞治疗的影响,以开发有效的再生康复方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Opinion in Biomedical Engineering
Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
2.60%
发文量
59
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