Early Loss of Spiral Ganglion Neurons in the Auditory System after Noise Trauma.

IF 1.6 4区医学 Q2 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Audiology and Neuro-Otology Pub Date : 2024-05-15 DOI:10.1159/000539359

Moritz Gröschel, Tanyo Manchev, Felix Fröhlich, Stefan Voigt, Arne Ernst, Dietmar Basta

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引用次数: 0

Abstract

Introduction: Noise-induced hearing loss is one of the most frequent recognized occupational diseases. The time course of the involved pathologies is still under investigation. Several studies have demonstrated an acute damage of the sensory tissue, but only few experiments investigated the degeneration of (type I) spiral ganglion neurons (SGNs), representing the primary neurons in the auditory system. The aim of the present study was to investigate the time course of SGN degeneration within a 7-day period after traumatic noise exposure starting immediately after trauma.

Methods: Young adult normal hearing mice were noise exposed for 3 h with a broadband noise (5-20 kHz) at 115 dB SPL. Auditory threshold shift was measured by auditory brainstem recordings, and SGN densities were analyzed at different time points during the first week after acoustic trauma.

Results: Significant reduction of SGN densities was detected and is accompanied by a significant hearing loss. Degeneration starts within hours after the applied trauma, further progressing within days post-exposure.

Discussion: Early neurodegeneration in the auditory periphery seems to be induced by direct overstimulation of the auditory nerve fibers. SGN loss is supposed to be a result of inflammatory responses and neural deprivation, leading to permanent hearing loss and auditory processing deficits.

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噪音创伤后听觉系统中螺旋神经节神经元的早期损失。

导言：噪声性听力损失（NIHL）是最常见的职业病之一。有关病变的时间过程仍在研究之中。有几项研究证明了感觉组织的急性损伤，但只有少数实验调查了代表听觉系统初级神经元的（I型）螺旋神经节神经元（SGN）的变性。本研究的目的是调查外伤性噪声暴露后 7 天内 SGN 退化的时间过程：方法：将听力正常的成年小鼠暴露于115 dB SPL的宽带噪声（5 - 20 kHz）中3小时。通过听觉脑干记录（ABR）测量听觉阈值偏移，并分析声创伤后第一周内不同时间点的 SGN 密度：结果：发现 SGN 密度显著降低，并伴有明显的听力损失。变性在声创伤后数小时内开始，并在暴露后数天内进一步发展：讨论：听觉外围的早期神经变性似乎是由听觉神经纤维直接受到过度刺激引起的。SGN 的缺失应该是炎症反应和神经剥夺的结果，从而导致永久性听力损失和听觉处理障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Audiology and Neuro-Otology 医学-耳鼻喉科学

CiteScore

3.20

自引率

6.20%

发文量

审稿时长

>12 weeks

期刊介绍： ''Audiology and Neurotology'' provides a forum for the publication of the most-advanced and rigorous scientific research related to the basic science and clinical aspects of the auditory and vestibular system and diseases of the ear. This journal seeks submission of cutting edge research opening up new and innovative fields of study that may improve our understanding and treatment of patients with disorders of the auditory and vestibular systems, their central connections and their perception in the central nervous system. In addition to original papers the journal also offers invited review articles on current topics written by leading experts in the field. The journal is of primary importance for all scientists and practitioners interested in audiology, otology and neurotology, auditory neurosciences and related disciplines.