Key factors in the choice of appropriate outcomes for clinical trials.

IF 1.2 Q2 MEDICINE, GENERAL & INTERNAL
Carlos Cabrera-Ubilla, Vicente Nuñez-Galleguillos, Javier Bracchiglione, Roberto Garnham, Ignacio Pérez
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引用次数: 0

Abstract

Health research is the foundation of medical knowledge and healthcare system recommendations. Therefore, choosing appropriate outcomes in studies of therapeutic interventions is a fundamental step in producing evidence and, subsequently, for decision-making. In this article, we propose three key factors for the choice of outcomes: the inclusion of patient-reported outcomes, since they focus on the patient's perception of their health status and quality of life; the consideration of clinically relevant outcomes, which are direct measurements of the patient's health status and, therefore, will be decisive in decision-making; and the use of core outcome sets, a tool that standardizes the measurement and interpretation of outcomes, facilitating the production and synthesis of appropriate evidence for the evidence ecosystem. The correct choice of outcomes will help health decision-makers and clinicians deliver appropriate patient-centered care and optimize the use of resources in healthcare and clinical research.

为临床试验选择适当结果的关键因素。
健康研究是医学知识和医疗保健系统建议的基础。因此,在治疗干预研究中选择适当的结果是产生证据的基本步骤,也是决策的基本步骤。在本文中,我们提出了选择结果的三个关键因素:纳入患者报告的结果,因为这些结果侧重于患者对其健康状况和生活质量的感知;考虑临床相关结果,因为这些结果是对患者健康状况的直接测量,因此在决策中起决定性作用;使用核心结果集,这是一种对结果的测量和解释进行标准化的工具,有助于为证据生态系统提供和综合适当的证据。正确选择结果将有助于卫生决策者和临床医生提供以患者为中心的适当护理,并优化医疗保健和临床研究资源的使用。
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来源期刊
Medwave
Medwave MEDICINE, GENERAL & INTERNAL-
CiteScore
2.60
自引率
8.30%
发文量
50
审稿时长
12 weeks
期刊介绍: Medwave is a peer-reviewed, biomedical and public health journal. Since its foundation in 2001 (Volume 1) it has always been an online only, open access publication that does not charge subscription or reader fees. Since January 2011 (Volume 11, Number 1), all articles are peer-reviewed. Without losing sight of the importance of evidence-based approach and methodological soundness, the journal accepts for publication articles that focus on providing updates for clinical practice, review and analysis articles on topics such as ethics, public health and health policy; clinical, social and economic health determinants; clinical and health research findings from all of the major disciplines of medicine, medical science and public health. The journal does not publish basic science manuscripts or experiments conducted on animals. Until March 2013, Medwave was publishing 11-12 numbers a year. Each issue would be posted on the homepage on day 1 of each month, except for Chile’s summer holiday when the issue would cover two months. Starting from April 2013, Medwave adopted the continuous mode of publication, which means that the copyedited accepted articles are posted on the journal’s homepage as they are ready. They are then collated in the respective issue and included in the Past Issues section.
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