The phenotypic changes of Schwann cells promote the functional repair of nerve injury

IF 2.5 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Neuropeptides Pub Date : 2024-05-11 DOI:10.1016/j.npep.2024.102438

Shufen Liao , Yan Chen , Yin Luo , Mengqi Zhang , Jun Min

引用次数: 0

Abstract

Functional recovery after nerve injury is a significant challenge due to the complex nature of nerve injury repair and the non-regeneration of neurons. Schwann cells (SCs), play a crucial role in the nerve injury repair process because of their high plasticity, secretion, and migration abilities. Upon nerve injury, SCs undergo a phenotypic change and redifferentiate into a repair phenotype, which helps in healing by recruiting phagocytes, removing myelin fragments, promoting axon regeneration, and facilitating myelin formation. However, the repair phenotype can be unstable, limiting the effectiveness of the repair. Recent research has found that transplantation of SCs can be an effective treatment option, therefore, it is essential to comprehend the phenotypic changes of SCs and clarify the related mechanisms to develop the transplantation therapy further.

查看原文本刊更多论文

许旺细胞的表型变化促进了神经损伤的功能修复。

由于神经损伤修复的复杂性和神经元的不可再生性，神经损伤后的功能恢复是一项重大挑战。许旺细胞（SCs）具有高度的可塑性、分泌和迁移能力，因此在神经损伤修复过程中发挥着至关重要的作用。神经损伤后，许旺细胞会发生表型变化，重新分化为修复表型，通过招募吞噬细胞、清除髓鞘碎片、促进轴突再生和促进髓鞘形成来帮助愈合。然而，修复表型可能不稳定，从而限制了修复的有效性。最近的研究发现，移植自体表皮细胞是一种有效的治疗方法，因此，了解自体表皮细胞的表型变化并阐明相关机制对进一步发展移植疗法至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Neuropeptides 医学-内分泌学与代谢

CiteScore

5.40

自引率

6.90%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of Neuropeptides is the rapid publication of original research and review articles, dealing with the structure, distribution, actions and functions of peptides in the central and peripheral nervous systems. The explosion of research activity in this field has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The journal provides a unique opportunity of integrating the many disciplines involved in all neuropeptide research. The journal publishes articles on all aspects of the neuropeptide field, with particular emphasis on gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.