Divergent association between pain intensity and resting-state fMRI-based brain entropy in different age groups

IF 2.9 3区医学 Q2 NEUROSCIENCES

Journal of Neuroscience Research Pub Date : 2024-05-15 DOI:10.1002/jnr.25341

Gianpaolo Del Mauro, Landrew Samuel Sevel, Jeff Boissoneault, Ze Wang

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Abstract

Pain is a multidimensional subjective experience sustained by multiple brain regions involved in different aspects of pain experience. We used brain entropy (BEN) estimated from resting-state fMRI (rsfMRI) data to investigate the neural correlates of pain experience. BEN was estimated from rs-fMRI data provided by two datasets with different age range: the Human Connectome Project-Young Adult (HCP-YA) and the Human Connectome project-Aging (HCP-A) datasets. Retrospective assessment of experienced pain intensity was retrieved from both datasets. No main effect of pain intensity was observed. The interaction between pain and age, however, was related to increased BEN in several pain-related brain regions, reflecting greater variability of spontaneous brain activity. Dividing the sample into a young adult group (YG) and a middle age-aging group (MAG) resulted in two divergent patterns of pain–BEN association: In the YG, pain intensity was related to reduced BEN in brain regions involved in the sensory processing of pain; in the MAG, pain was associated with increased BEN in areas related to both sensory and cognitive aspects of pain experience.

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不同年龄组的疼痛强度与基于静息态 fMRI 的大脑熵之间存在差异。

疼痛是一种多维度的主观体验，由涉及疼痛体验不同方面的多个脑区共同维持。我们利用静息态 fMRI（rsfMRI）数据估算出的大脑熵（BEN）来研究疼痛体验的神经相关性。BEN是根据两个不同年龄段的数据集提供的rs-fMRI数据估算的，这两个数据集是：人类连接组计划-年轻成人数据集（HCP-YA）和人类连接组计划-老龄化数据集（HCP-A）。从这两个数据集中检索了对所经历的疼痛强度的回顾性评估。没有观察到疼痛强度的主效应。然而，疼痛与年龄之间的交互作用与几个疼痛相关脑区的 BEN 增加有关，这反映了自发脑活动的更大变异性。将样本分为青年组（YG）和中老年组（MAG）会产生两种不同的疼痛-BEN关联模式：在青年组中，疼痛强度与涉及疼痛感觉处理的大脑区域的 BEN 减少有关；而在中年组中，疼痛与涉及疼痛体验的感觉和认知方面的区域的 BEN 增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuroscience Research 医学-神经科学

CiteScore

9.50

自引率

2.40%

发文量

145

审稿时长

1 months

期刊介绍： The Journal of Neuroscience Research (JNR) publishes novel research results that will advance our understanding of the development, function and pathophysiology of the nervous system, using molecular, cellular, systems, and translational approaches. JNR covers both basic research and clinical aspects of neurology, neuropathology, psychiatry or psychology. The journal focuses on uncovering the intricacies of brain structure and function. Research published in JNR covers all species from invertebrates to humans, and the reports inform the readers about the function and organization of the nervous system, with emphasis on how disease modifies the function and organization.