Effects of Different Storage Times on the Stability of 12 Traditional Chinese Medicine Decoction Pieces.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-20 DOI:10.1093/chromsci/bmae030

Rui-Fang Xie, Yi-Ming Feng, Shan-Ni Li, Wei-Song Kong, Gui Zhou, Xin Zhou

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引用次数: 0

Abstract

As storage time increases, the quality of traditional Chinese medicines (TCMs) may change, and stability is an essential aspect of ensuring the safety and efficacy of TCMs. In this study, the effects of different storage times on the stability of 12 decoction pieces were evaluated. High-performance liquid chromatography was used to determine the contents of the active components in the 12 decoction pieces. The chemical composition data were analyzed using fingerprinting and clustering heatmap (CH). Results showed that during storage, significant variations (relative standard deviation > 10%) were observed in the levels of paeoniflorin in Paeoniae Radix Alba and Paeoniae Radix Rubra, hesperidin in Citri Reticulatae Pericarpium and Citri Reticulatae Pericarpium Viride, bufothionine in Siccus Bufo and chlorogenic acid in White Chrysanthemi Flos and Lonice Raejaponicae Caulis. However, calycosin-7-glucoside and calycosin in Astragali Radix Praeparata Cum Melle and chlorogenic acid in Lonicerae Japonicae Flos, Yellow Chrysanthemi Flos and Mori Folium were all <10%, which is consistent with the CH. Decoction pieces can be stored for up to six months, but it is recommended that volatile oil-containing and animal-based decoction pieces should not be stored for more than one month. This study provides new perspectives for the stability and quality control studies of TCM.

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不同储存时间对 12 味中药煎剂稳定性的影响

随着贮藏时间的延长，中药的质量可能会发生变化，而稳定性是确保中药安全性和有效性的一个重要方面。本研究评估了不同储存时间对 12 味煎药稳定性的影响。采用高效液相色谱法测定了 12 味煎药中有效成分的含量。化学成分数据采用指纹图谱和聚类热图（CH）进行分析。结果表明，在贮藏过程中，白芍和赤芍中的芍药苷、陈皮和陈皮中的橙皮甙、蛇床子中的牛磺酸、白菊花和龙葵中的绿原酸含量有明显变化（相对标准偏差大于 10%）。然而，黄芪中的钙苷-7-葡萄糖苷和钙苷，以及日本忍冬花、黄菊花和桑叶中的绿原酸都是

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.