What to do when traditional rescue therapies fail in acute severe ulcerative colitis.

IF 3.4 Q2 GASTROENTEROLOGY & HEPATOLOGY

Intestinal Research Pub Date : 2024-10-01 Epub Date: 2024-05-16 DOI:10.5217/ir.2024.00003

Christopher F D Li Wai Suen, Matthew C Choy, Peter De Cruz

引用次数: 0

Abstract

Acute severe ulcerative colitis (ASUC) is a medical emergency that affects approximately 25% of patients with ulcerative colitis at some point in time in their lives. Outcomes of ASUC are highly variable. Approximately 30% of patients do not respond to corticosteroids and up to 50% of patients do not respond to rescue therapy (infliximab or cyclosporin) and require emergency colectomy. Data are emerging on infliximab dosing strategies, use of cyclosporin as a bridge to slower acting biologic agents and Janus kinase inhibition as primary and sequential therapy. In this review, we outline contemporary approaches to clinical management of ASUC in the setting of failure to respond to traditional rescue therapies.

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当急性重度溃疡性结肠炎的传统抢救疗法失效时该怎么办？

急性重度溃疡性结肠炎（ASUC）是一种医疗急症，约有 25% 的溃疡性结肠炎患者在一生中的某个阶段会受到这种疾病的影响。急性重症溃疡性结肠炎的治疗结果变化很大。约 30% 的患者对皮质类固醇激素无效，高达 50% 的患者对抢救疗法（英夫利昔单抗或环孢素）无效，需要进行紧急结肠切除术。有关英夫利昔单抗剂量策略、使用环孢素作为通向作用较慢的生物制剂的桥梁以及将 Janus 激酶抑制剂作为主要和序贯疗法的数据不断涌现。在这篇综述中，我们概述了在传统抢救疗法无效的情况下临床治疗 ASUC 的现代方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Intestinal Research GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

7.40

自引率

10.20%

发文量

审稿时长

38 weeks

期刊介绍： Intestinal Research (Intest Res) is the joint official publication of the Asian Organization for Crohn''s and Colitis (AOCC), Chinese Society of IBD (CSIBD), Japanese Society for IBD (JSIBD), Korean Association for the Study of Intestinal Diseases (KASID), Taiwan Society of IBD (TSIBD) and Colitis Crohn''s Foundation (India) (CCF, india). The aim of the Journal is to provide broad and in-depth analysis of intestinal diseases, especially inflammatory bowel disease, which shows increasing tendency and significance. As a Journal specialized in clinical and translational research in gastroenterology, it encompasses multiple aspects of diseases originated from the small and large intestines. The Journal also seeks to propagate and exchange useful innovations, both in ideas and in practice, within the research community. As a mode of scholarly communication, it encourages scientific investigation through the rigorous peer-review system and constitutes a qualified and continual platform for sharing studies of researchers and practitioners. Specifically, the Journal presents up-to-date coverage of medical researches on the physiology, epidemiology, pathophysiology, clinical presentations, and therapeutic interventions of the intestinal diseases. General topics of interest include inflammatory bowel disease, colon and small intestine cancer or polyp, endoscopy, irritable bowel syndrome and other motility disorders, infectious enterocolitis, intestinal tuberculosis, and so forth. The Journal publishes diverse types of academic materials such as editorials, clinical and basic reviews, original articles, case reports, letters to the editor, brief communications, perspective, statement or commentary, and images that are useful to clinicians and researchers.