Stimuli-sensitive Chitosan-based Nanosystems-immobilized Nucleic Acids for Gene Therapy in Breast Cancer and Hepatocellular Carcinoma.

IF 2.9 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2024-01-01 DOI:10.2174/0115680266293173240506054439

Seyed Morteza Naghib, Bahar Ahmadi, M R Mozafari

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引用次数: 0

Abstract

Chitosan-based nanoparticles have emerged as a promising tool in the realm of cancer therapy, particularly for gene delivery. With cancer being a prevalent and devastating disease, finding effective treatment options is of utmost importance. These nanoparticles provide a unique solution by encapsulating specific genes and delivering them directly to cancer cells, offering immense potential for targeted therapy. The biocompatibility and biodegradability of chitosan, a naturally derived polymer, make it an ideal candidate for this purpose. The nanoparticles protect the genetic material during transportation and enhance its cellular uptake, ensuring effective delivery to the site of action. Furthermore, the unique properties of chitosan-based nanoparticles allow for the controlled release of genes, maximizing their therapeutic effect while minimizing adverse effects. By advancing the field of gene therapy through the use of chitosan-based nanoparticles, scientists are making significant strides toward more humane and personalized treatments for cancer patients.

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用于乳腺癌和肝细胞癌基因治疗的对刺激敏感的壳聚糖基纳米系统固定化核酸

壳聚糖基纳米粒子已成为癌症治疗领域的一种前景广阔的工具，尤其是用于基因递送。癌症是一种普遍存在的毁灭性疾病，因此找到有效的治疗方案至关重要。这些纳米颗粒提供了一种独特的解决方案，它们封装了特定基因并将其直接输送到癌细胞，为靶向治疗提供了巨大的潜力。壳聚糖是一种天然聚合物，其生物相容性和生物可降解性使其成为实现这一目的的理想候选材料。这种纳米颗粒在运输过程中保护遗传物质，并提高细胞对其的吸收率，从而确保将药物有效送达作用部位。此外，壳聚糖基纳米粒子的独特性能还能控制基因的释放，最大限度地提高治疗效果，同时将不良反应降至最低。通过使用壳聚糖基纳米粒子推进基因治疗领域的发展，科学家们在为癌症患者提供更加人性化和个性化的治疗方面取得了重大进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.