Treadmill exercise promotes bone tissue recovery in rats subjected to high + Gz loads.

IF 2.4 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Journal of Bone and Mineral Metabolism Pub Date : 2024-05-01 Epub Date: 2024-05-16 DOI:10.1007/s00774-024-01513-7

Lilan Gao, Ruiqi Chen, Xianglong Lin, Jie Liu, Jin Liu, Yansong Tan, Chunqiu Zhang, Xizheng Zhang

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Abstract

Introduction: High + Gz loads, the gravitational forces experienced by the body in hypergravity environments, can lead to bone loss in pilots and astronauts, posing significant health risks.

Materials and methods: To explore the effect of treadmill exercise on bone tissue recovery, a study was conducted on 72 male Wistar rats. These rats were subjected to four weeks of varying levels of periodic high + Gz loads (1G, 8G, 20G) experiments, and were subsequently divided into the treadmill group and the control group. The treadmill group underwent a continuous two-week treadmill experiment, while the control group rested during this period. The mechanical properties, microstructure, and molecular markers of their tibial bone tissue were measured using three-point bending, micro-CT, and PCR.

Results: The results showed that treadmill exercise improved the elastic modulus, ultimate deflection, and ultimate load of rat bone tissue. It also increased the number, density, and volume fraction of bone trabeculae, and decreased their separation. Moreover, treadmill exercise enhanced osteogenesis and inhibited osteoclastogenesis.

Conclusion: This study demonstrates that treadmill exercise can promote the recovery of bone tissue in rats subjected to high + Gz loads, providing a potential countermeasure for bone loss in pilots and astronauts.

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跑步机运动可促进承受高 + Gz 负荷的大鼠骨组织恢复。

导言：高 + Gz 负荷，即人体在超重力环境中经历的重力，可导致飞行员和宇航员骨质流失，对健康构成重大风险：为了探索跑步机运动对骨组织恢复的影响，我们对 72 只雄性 Wistar 大鼠进行了研究。这些大鼠接受了四周不同程度的周期性高+Gz负荷（1G、8G、20G）实验，随后被分为跑步机组和对照组。跑步机组进行连续两周的跑步机实验，而对照组在此期间休息。研究人员使用三点弯曲、显微 CT 和 PCR 测量了胫骨组织的机械性能、微观结构和分子标记：结果表明，跑步机运动提高了大鼠骨组织的弹性模量、极限挠度和极限载荷。结果表明：跑步机运动提高了大鼠骨组织的弹性模量、极限挠度和极限载荷，还增加了骨小梁的数量、密度和体积分数，减少了骨小梁的分离。此外，跑步机运动还能促进骨生成，抑制破骨细胞生成：本研究表明，跑步机运动可以促进承受高+Gz负荷的大鼠骨组织的恢复，为飞行员和宇航员的骨质流失提供了一种潜在的对策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Bone and Mineral Metabolism 医学-内分泌学与代谢

CiteScore

6.30

自引率

3.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Bone and Mineral Metabolism (JBMM) provides an international forum for researchers and clinicians to present and discuss topics relevant to bone, teeth, and mineral metabolism, as well as joint and musculoskeletal disorders. The journal welcomes the submission of manuscripts from any country. Membership in the society is not a prerequisite for submission. Acceptance is based on the originality, significance, and validity of the material presented. The journal is aimed at researchers and clinicians dedicated to improvements in research, development, and patient-care in the fields of bone and mineral metabolism.