Subtle Radiographic Progression at Six Months Can Be Detected Using Automated Quantitative Software in Rheumatoid Arthritis While Receiving Tocilizumab.

IF 1.8 4区医学 Q3 RHEUMATOLOGY

Modern Rheumatology Pub Date : 2024-05-16 DOI:10.1093/mr/roae047

Taichi Okino, Yafei Ou, Masayuki Ikebe, Akira Furusaki, Akira Sagawa, Masaru Kato, Tatsuya Atsumi, Kenneth Sutherland, Tamotsu Kamishima

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引用次数: 0

Abstract

Objectives: We investigated whether our in-house software equipped with partial image phase-only correlation (PIPOC) can detect subtle radiographic joint space narrowing (JSN) progression at six months and predict JSN progression in rheumatoid arthritis (RA) patients receiving Tocilizumab.

Methods: The study included 39 RA patients who were treated with Tocilizumab. Radiological progression of the metacarpophalangeal and the proximal interphalangeal joints was evaluated according to the Genant-modified Sharp score (GSS) at 0, 6, and 12 months. Automatic measurements were performed with the software. We validated the software in terms of accuracy in detecting the JSN progression.

Results: The success rate of the software for joint space width (JSW) measurement was 96.8% (449/464). The 0-12-month JSW change by the software was significantly greater in joints with the 0-6-month PIPOC (+) group than the 0-6-month PIPOC (-) group (p < 0.001). The 0-12-month JSW change by the software was 0-12-month GSS (+) than with 0-12-month GSS (-) (p = 0.02). Here, "(+)" indicates the JSN progression during the follow-up period. Meanwhile, "(-)" indicates no JSN progression during the follow-up period. Linear regression tests showed significant correlations between the 0-6-month and the 0-12-month PIPOC in the left 2nd and 3rd MCP joints (R2 = 0.554 and 0.420, respectively).

Conclusions: Our in-house software equipped with PIPOC could predict subsequent JSN progression with only short-term observations.

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使用自动定量软件可检测类风湿关节炎患者在接受托昔单抗治疗六个月后的细微放射学进展。

目的：我们研究了配备部分图像相位相关性（PIPOC）的内部软件是否能检测类风湿性关节炎（RA）患者六个月时细微的影像学关节间隙狭窄（JSN）进展并预测JSN进展：研究纳入了39名接受妥昔单抗治疗的RA患者。根据Genant-modified Sharp评分（GSS）评估掌指关节和近端指间关节在0、6和12个月时的放射学进展。自动测量由软件完成。我们验证了该软件在检测 JSN 进展方面的准确性：结果：该软件测量关节间隙宽度（JSW）的成功率为 96.8%（449/464）。软件测量的0-12个月关节间隙宽度变化，0-6个月PIPOC（+）组明显大于0-6个月PIPOC（-）组（p < 0.001）。软件显示的 0-12 个月 JSW 变化为 0-12 个月 GSS (+) 大于 0-12 个月 GSS (-) (p = 0.02)。这里的"（+）"表示随访期间的 JSN 进展。同时，"（-）"表示随访期间无 JSN 进展。线性回归测试显示，左侧第 2 和第 3 MCP 关节 0-6 个月和 0-12 个月的 PIPOC 之间存在明显相关性（R2 分别为 0.554 和 0.420）：结论：我们配备 PIPOC 的内部软件仅通过短期观察就能预测 JSN 的后续进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Modern Rheumatology RHEUMATOLOGY-

CiteScore

4.90

自引率

9.10%

发文量

146

审稿时长

1.5 months

期刊介绍： Modern Rheumatology publishes original papers in English on research pertinent to rheumatology and associated areas such as pathology, physiology, clinical immunology, microbiology, biochemistry, experimental animal models, pharmacology, and orthopedic surgery. Occasional reviews of topics which may be of wide interest to the readership will be accepted. In addition, concise papers of special scientific importance that represent definitive and original studies will be considered. Modern Rheumatology is currently indexed in Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, Academic OneFile, Current Abstracts, Elsevier Biobase, Gale, Health Reference Center Academic, OCLC, SCImago, Summon by Serial Solutions