Identification of a novel QTL for lean meat percentage using imputed genotypes

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-05-16 DOI:10.1111/age.13442

Emil Ibragimov, Anni Øyan Pedersen, Niels Morten Sloth, Merete Fredholm, Peter Karlskov-Mortensen

引用次数: 0

Abstract

Lean meat percentage is a critical production trait in pig breeding systems with direct implications for the sustainability of the industry. In this study, we conducted a genome-wide association study for lean meat percentage using a cohort of 850 Duroc × (Landrace × Yorkshire) crossbred pigs and we identified QTL on SSC3 and SSC18. Based on the predicted effect of imputed variants and using the PigGTEx database of molecular QTL, we prioritized candidate genes and SNPs located within the QTL regions, which may be involved in the regulation of porcine leanness. Our results indicate that a nonsense mutation in ZC3HAV1L on SSC18 has a direct effect on lean meat percentage.

Abstract Image

查看原文本刊更多论文

利用推算基因型鉴定瘦肉率的新型 QTL。

瘦肉率是猪育种系统中的一个关键生产性状，对猪业的可持续发展具有直接影响。在本研究中，我们利用 850 头杜洛克×（兰德瑞斯×约克夏）杂交猪进行了瘦肉率的全基因组关联研究，并在 SSC3 和 SSC18 上鉴定出了 QTL。根据推算变异的预测效应并利用 PigGTEx 分子 QTL 数据库，我们优先选择了 QTL 区域内可能参与猪瘦肉率调控的候选基因和 SNP。我们的结果表明，SSC18 上 ZC3HAV1L 的无义突变对瘦肉率有直接影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.