Identification of a novel QTL for lean meat percentage using imputed genotypes

IF 1.8 3区生物学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Animal genetics Pub Date : 2024-05-16 DOI:10.1111/age.13442

Emil Ibragimov, Anni Øyan Pedersen, Niels Morten Sloth, Merete Fredholm, Peter Karlskov-Mortensen

引用次数: 0

Abstract

Lean meat percentage is a critical production trait in pig breeding systems with direct implications for the sustainability of the industry. In this study, we conducted a genome-wide association study for lean meat percentage using a cohort of 850 Duroc × (Landrace × Yorkshire) crossbred pigs and we identified QTL on SSC3 and SSC18. Based on the predicted effect of imputed variants and using the PigGTEx database of molecular QTL, we prioritized candidate genes and SNPs located within the QTL regions, which may be involved in the regulation of porcine leanness. Our results indicate that a nonsense mutation in ZC3HAV1L on SSC18 has a direct effect on lean meat percentage.

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利用推算基因型鉴定瘦肉率的新型 QTL。

瘦肉率是猪育种系统中的一个关键生产性状，对猪业的可持续发展具有直接影响。在本研究中，我们利用 850 头杜洛克×（兰德瑞斯×约克夏）杂交猪进行了瘦肉率的全基因组关联研究，并在 SSC3 和 SSC18 上鉴定出了 QTL。根据推算变异的预测效应并利用 PigGTEx 分子 QTL 数据库，我们优先选择了 QTL 区域内可能参与猪瘦肉率调控的候选基因和 SNP。我们的结果表明，SSC18 上 ZC3HAV1L 的无义突变对瘦肉率有直接影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Animal genetics 生物-奶制品与动物科学

CiteScore

4.60

自引率

4.20%

发文量

115

审稿时长

5 months

期刊介绍： Animal Genetics reports frontline research on immunogenetics, molecular genetics and functional genomics of economically important and domesticated animals. Publications include the study of variability at gene and protein levels, mapping of genes, traits and QTLs, associations between genes and traits, genetic diversity, and characterization of gene or protein expression and control related to phenotypic or genetic variation. The journal publishes full-length articles, short communications and brief notes, as well as commissioned and submitted mini-reviews on issues of interest to Animal Genetics readers.