Efficacy of Self-Review of Lifestyle Behaviors with Once-Weekly Glycated Albumin Measurement in People with Type 2 Diabetes: A Randomized Pilot Study.

IF 3.8 3区医学 Q2 Medicine

Diabetes Therapy Pub Date : 2024-07-01 Epub Date: 2024-05-16 DOI:10.1007/s13300-024-01599-2

Hideaki Jinnouchi, Akira Yoshida, Mariko Taniguchi, Eisaku Yamauchi, Daisuke Kurosawa, Kenji Yachiku, Itsushi Minoura, Takashi Kadowaki, Toshimasa Yamauchi, Masakazu Aihara, Naoto Kubota, Koshin Sekimizu

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Abstract

Introduction: Lifestyle management, including appropriate modifications of nutrition, exercise, and medication behaviors, is essential for optimal glycemic control. The absence of appropriate monitoring methods to validate the lifestyle change may hinder the modification and continuation of behaviors. In this study, we evaluated whether once-weekly glycated albumin (GA) measurement received via a smartphone application could improve glycemia management in patients with type 2 diabetes mellitus by supporting self-review and modification of lifestyle behaviors.

Methods: This open-label, randomized controlled, single-center study in Japan with an 8-week intervention period was conducted in individuals with type 2 diabetes mellitus and HbA1c levels between 7.0 and 9.0% (53‒75 mmol/mol). The intervention was once-weekly home monitoring of GA with a daily self-review of lifestyle behaviors using a smartphone application, in addition to conventional treatment.

Results: A total of 98 participants (72.0% males; age 63.2 ± 11.4 years; HbA1c 7.39 ± 0.39% [57.3 ± 4.3 mmol/mol]) were randomly assigned to the intervention or control group. Significant decreases of the GA and HbA1c levels from the baseline to the last observation day were observed in the intervention group (- 1.71 ± 1.37% [- 39.1 ± 31.3 mmol/mol] and - 0.32 ± 0.32% [- 3.5 ± 3.5 mmol/mol], respectively). Significant decreases of the body weight, waist circumference, and caloric expenditure (p < 0.0001 and p = 0.0003, p = 0.0346, respectively), but not of the caloric intake (p = 0.678), were also observed in the intervention group as compared with the control group.

Conclusions: Self-review of lifestyle behaviors in combination with once-weekly GA home testing received via a smartphone application might potentially benefit glycemic management in people with type 2 diabetes mellitus.

Trial registration: jRCTs042220048.

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2 型糖尿病患者通过每周一次糖化白蛋白测量自我评估生活方式的效果：随机试点研究

导言：生活方式管理，包括营养、运动和用药行为的适当调整，对于实现最佳血糖控制至关重要。缺乏适当的监测方法来验证生活方式的改变可能会阻碍行为的改变和持续。在这项研究中，我们评估了通过智能手机应用程序接受每周一次的糖化白蛋白（GA）测量是否能通过支持自我审查和生活方式行为的改变来改善 2 型糖尿病患者的血糖管理：这项开放标签、随机对照、单中心研究在日本进行，干预期为 8 周，对象为 HbA1c 水平在 7.0% 到 9.0% 之间（53-75 mmol/mol）的 2 型糖尿病患者。干预措施是在常规治疗的基础上，每周一次在家监测血糖，每天使用智能手机应用程序对生活方式进行自我评估：共有 98 名参与者（72.0% 为男性；年龄为 63.2 ± 11.4 岁；HbA1c 为 7.39 ± 0.39% [57.3 ± 4.3 mmol/mol]）被随机分配到干预组或对照组。干预组的 GA 和 HbA1c 水平从基线到最后观察日均有显著下降（分别为 - 1.71 ± 1.37% [- 39.1 ± 31.3 mmol/mol] 和 - 0.32 ± 0.32% [- 3.5 ± 3.5 mmol/mol]）。体重、腰围和热量消耗均有显著下降（p 结论）：通过智能手机应用程序接受每周一次的GA家庭检测，结合生活方式行为的自我审查可能会对2型糖尿病患者的血糖管理产生潜在的益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes Therapy Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

6.90

自引率

7.90%

发文量

130

审稿时长

6 weeks

期刊介绍： Diabetes Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all areas of diabetes. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Diabetes Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.