Predentin's influence on clastic cell behavior in human external cervical resorption: Evidence from a case study

IF 3.4 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences Pub Date : 2024-07-01 DOI:10.1016/j.jds.2024.04.023

Toshihiro Noma , Shohei Yoshimoto , Yasuhiko Kamura , Masaki Arioka

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引用次数: 0

Abstract

External cervical resorption (ECR) is an aggressive disease characterized by resorption of the tooth root structure. While the pericanalar resorption-resistant sheet (PRRS) impedes ECR progression towards the pulp, the underlying mechanisms of its protective role in human teeth remain unclear. This study aimed to elucidate the pathology of ECR in a 31-year-old female patient by employing radiographic, histological, and immunohistochemical analyses of an extracted tooth. Histological examination revealed that the PRRS comprised dentin, predentin, and reparative bone-like tissue. Notably, clastic cells were observed on the surfaces of all three tissues within the same specimens. Immunohistochemical staining for cathepsin K demonstrated diminished resorptive activity of clastic cells on predentin compared to dentin and bone-like tissue. These findings suggest a potential role for predentin in attenuating clastic cell activity, potentially serving as the final barrier safeguarding the pulp tissue.

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Predentin 对人类宫颈外口吸收过程中碎屑细胞行为的影响：病例研究的证据

外牙颈部吸收（ECR）是一种以牙根结构吸收为特征的侵袭性疾病。虽然牙周抗吸收片（PRRS）能阻止 ECR 向牙髓发展，但其在人类牙齿中发挥保护作用的基本机制仍不清楚。本研究旨在通过对一颗拔出的牙齿进行放射学、组织学和免疫组化分析，阐明一位 31 岁女性患者的 ECR 病理学。组织学检查显示，PRRS 由牙本质、前牙本质和修复骨样组织组成。值得注意的是，在同一标本的所有三种组织表面都观察到了碎屑细胞。cathepsin K免疫组化染色显示，与牙本质和类骨组织相比，前牙本质上的碎屑细胞的吸收活性减弱。这些研究结果表明，牙本质在减弱碎屑细胞活性方面具有潜在的作用，有可能成为保护牙髓组织的最后一道屏障。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Dental Sciences 医学-牙科与口腔外科

CiteScore

5.10

自引率

14.30%

发文量

348

审稿时长

6 days

期刊介绍： he Journal of Dental Sciences (JDS), published quarterly, is the official and open access publication of the Association for Dental Sciences of the Republic of China (ADS-ROC). The precedent journal of the JDS is the Chinese Dental Journal (CDJ) which had already been covered by MEDLINE in 1988. As the CDJ continued to prove its importance in the region, the ADS-ROC decided to move to the international community by publishing an English journal. Hence, the birth of the JDS in 2006. The JDS is indexed in the SCI Expanded since 2008. It is also indexed in Scopus, and EMCare, ScienceDirect, SIIC Data Bases. The topics covered by the JDS include all fields of basic and clinical dentistry. Some manuscripts focusing on the study of certain endemic diseases such as dental caries and periodontal diseases in particular regions of any country as well as oral pre-cancers, oral cancers, and oral submucous fibrosis related to betel nut chewing habit are also considered for publication. Besides, the JDS also publishes articles about the efficacy of a new treatment modality on oral verrucous hyperplasia or early oral squamous cell carcinoma.