New Cobalt Complex with Dihydroxycoumarin: Synthesis and Kinetics of Its Redox-Activated Dissociation

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-05-08 DOI:10.1134/S1070328423600663

K. A. Spiridonov, I. A. Nikovskii, E. P. Antoshkina, E. A. Khakina, Yu. V. Nelyubina

引用次数: 0

Abstract

A new redox-active cobalt(III) complex containing the 2-oxo-2Н-chromene-6,7-diolate dianion and 4,4'-dimethoxy-2,2'-bipyridine as ligands is synthesized. The reduction of the synthesized complex with ascorbic acid in an inert atmosphere is studied in situ by NMR spectroscopy. The reduction is shown to result in the release of 6,7-dihydrocycoumarin acting as a model drug. This process has the first order with respect to the initial complex.

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二羟基香豆素的新钴配合物：合成及其氧化还原激活解离动力学

摘要合成了一种新的具有氧化还原活性的钴(III)配合物，该配合物含有 2-oxo-2Н-chromene-6,7-diolate 二离子和 4,4'-dimethoxy-2,2'-bipyridine 配体。在惰性气氛中，利用核磁共振光谱对合成复合物与抗坏血酸的还原过程进行了原位研究。研究表明，还原过程会导致作为模型药物的 6,7-二氢香豆素的释放。这一过程对于初始复合物而言是一阶的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.