La(III), Ce(III), Pr(III) and Eu(III) complexes with fenamic acid based ligands: preparation, spectral and thermal analysis and evaluation of their cytotoxicity in MDA-MB-231 breast cancer cells

IF 2.2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Iranian Chemical Society Pub Date : 2024-05-08 DOI:10.1007/s13738-024-03033-7

Hanan K. Mosbah, Ahmed B. M Ibrahim, Amna S. A. Zidan, Aref A. M. Aly, Saber H. Saber

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Abstract

Six lanthanide complexes with substituted fenamic acid ligands {[La(L¹)₃].2H₂O (C1), [La(L²)₃].2H₂O (C2), [Ce(L¹)₃] (C3), [Ce(L²)₃].2H₂O (C4), [Pr(L¹)₃].3H₂O (C5) and [Eu(L²)₃] (C6); HL¹ = 2-(4-chlorophenylamino)benzoic acid and HL²= 2-(4-methoxyphenylamino)benzoic acid} were isolated and characterized by elemental CHN microanalyses, DMF solution electrical conductivities and spectral (FTIR and UV–Visible) data. These analyses assigned the monoanionic character of the ligands and their bidentate chelation mode through the carboxylate group oxygen atoms. In addition, the complexes dissolve in dichloromethane, dimethylformamide and dimethyl sulfoxide, and are nonelectrolytes. Thermo-analytical techniques (TG/DTA) analyzed the complexes in the air and revealed that all water contained in them is lattice-based (uncoordinated), while complexes C3 and C6 are anhydrous. Moreover, all complexes, during heating up to 700 °C, decomposed to the respective oxides (Ln₂O₃). The complexes were tested for potential activity against human MDA-MB-231 breast cancer cells and the results uncovered low cytotoxic effect with high IC₅₀ doses, comparing to paclitaxel, on these cells.

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含有氨基甲酸配体的 La(III)、Ce(III)、Pr(III) 和 Eu(III) 复合物：制备、光谱和热分析及其在 MDA-MB-231 乳腺癌细胞中的细胞毒性评估

六种具有取代氨基甲酸配体的镧系配合物{[La(L1)3].2H2O (C1)、[La(L2)3].2H2O (C2)、[Ce(L1)3](C3)、[Ce(L2)3].2H2O (C4)、[Pr(L1)3].3H2O (C5) 和 [Eu(L2)3] (C6)；HL1 = 2-(4-氯苯胺基)苯甲酸和 HL2 = 2-(4-甲氧基苯胺基)苯甲酸}被分离出来，并通过元素 CHN 显微分析、DMF 溶液电导率和光谱（傅里叶变换红外光谱和紫外可见光光谱）数据对其进行了表征。这些分析表明了配体的单阴离子特性及其通过羧基氧原子的双齿螯合模式。此外，这些复合物溶于二氯甲烷、二甲基甲酰胺和二甲基亚砜，并且是非电解质。热分析技术（TG/DTA）对空气中的络合物进行了分析，结果表明它们所含的水都是晶格基（非配位）的，而络合物 C3 和 C6 则是无水的。此外，所有络合物在加热至 700 °C 时都会分解成相应的氧化物（Ln2O3）。研究人员测试了这些复合物对人类 MDA-MB-231 乳腺癌细胞的潜在活性，结果发现，与紫杉醇相比，这些复合物对这些细胞的细胞毒性较低，IC50 剂量较高。

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来源期刊

Journal of the Iranian Chemical Society 化学-化学综合

CiteScore

4.40

自引率

8.30%

发文量

230

审稿时长

5.6 months

期刊介绍： JICS is an international journal covering general fields of chemistry. JICS welcomes high quality original papers in English dealing with experimental, theoretical and applied research related to all branches of chemistry. These include the fields of analytical, inorganic, organic and physical chemistry as well as the chemical biology area. Review articles discussing specific areas of chemistry of current chemical or biological importance are also published. JICS ensures visibility of your research results to a worldwide audience in science. You are kindly invited to submit your manuscript to the Editor-in-Chief or Regional Editor. All contributions in the form of original papers or short communications will be peer reviewed and published free of charge after acceptance.