A Study of the Thermal Degradation of Amoxicillin Trihydrate Using Raman Spectroscopy and High-Performance Liquid Chromatography

IF 0.8 4区化学 Q4 SPECTROSCOPY

Journal of Applied Spectroscopy Pub Date : 2024-05-10 DOI:10.1007/s10812-024-01725-9

R. R. Davletshin, R. R. Galeev, I. R. Aryslanov, E. V. Galeeva, A. N. Sedov

引用次数: 0

Abstract

High-performance liquid chromatography (HPLC) and Raman spectroscopy have been used to study the thermal degradation of amoxicillin trihydrate. Heating this compound at 60°C for 6 h led to an increase in the impurity contents, each not exceeding 1%. HPLC and Raman spectroscopy can be used to evaluate the quality of an amoxicillin sample obtained after thermal degradation at 80°C.

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利用拉曼光谱和高效液相色谱法对三水阿莫西林热降解的研究

高效液相色谱法（HPLC）和拉曼光谱被用来研究三水阿莫西林的热降解。将这种化合物在 60°C 下加热 6 小时会导致杂质含量增加，但每个杂质含量都不超过 1%。高效液相色谱法和拉曼光谱可用于评估在 80°C 热降解后获得的阿莫西林样品的质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Applied Spectroscopy SPECTROSCOPY-

CiteScore

1.30

自引率

14.30%

发文量

145

审稿时长

2.5 months

期刊介绍： Journal of Applied Spectroscopy reports on many key applications of spectroscopy in chemistry, physics, metallurgy, and biology. An increasing number of papers focus on the theory of lasers, as well as the tremendous potential for the practical applications of lasers in numerous fields and industries.