Emergence and dissemination of SARS-CoV-2 XBB.1.5 in New York

IF 5.5 2区医学 Q1 VIROLOGY

Virus Evolution Pub Date : 2024-05-07 DOI:10.1093/ve/veae035

Fabiana Gambaro, Ralf Duerr, Dacia Dimartino, Christian Marier, Eduardo Iturrate, Mark J Mulligan, Adriana Heguy, Simon Dellicour

{"title":"Emergence and dissemination of SARS-CoV-2 XBB.1.5 in New York","authors":"Fabiana Gambaro, Ralf Duerr, Dacia Dimartino, Christian Marier, Eduardo Iturrate, Mark J Mulligan, Adriana Heguy, Simon Dellicour","doi":"10.1093/ve/veae035","DOIUrl":null,"url":null,"abstract":"The recombinant SARS-CoV-2 Omicron XBB.1.5 variant was first detected in New York City (NYC) and rapidly became the predominant variant in the area by early 2023. The increased occurrence of circulating variants within the SARS-CoV-2 XBB-sublineage prompted the modification of COVID-19 mRNA vaccines by Moderna and Pfizer-BioNTech. This update, implemented in mid-September 2023, involved the incorporation of a monovalent XBB.1.5 component. Considering that NYC probably played a central role in the emergence of the XBB.1.5 variant, we conducted phylogeographic analysis to investigate the emergence and spread of this variant in the metropolitan area. Our analysis confirms that XBB.1.5 emerged within or near the NYC area and indicates that XBB.1.5 had a diffusion velocity similar to that of the variant Alpha in the same study area. Additionally, the analysis of 2,392 genomes collected in the context of the genomic surveillance program at NYU Langone Health system (NYULH) showed that there was no increased proportion of XBB.1.5, relative to all cocirculating variants, in the boosted compared to unvaccinated individuals. This study provides a comprehensive description of the emergence and dissemination of XBB.1.5.","PeriodicalId":56026,"journal":{"name":"Virus Evolution","volume":"36 1","pages":""},"PeriodicalIF":5.5000,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Virus Evolution","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/ve/veae035","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VIROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The recombinant SARS-CoV-2 Omicron XBB.1.5 variant was first detected in New York City (NYC) and rapidly became the predominant variant in the area by early 2023. The increased occurrence of circulating variants within the SARS-CoV-2 XBB-sublineage prompted the modification of COVID-19 mRNA vaccines by Moderna and Pfizer-BioNTech. This update, implemented in mid-September 2023, involved the incorporation of a monovalent XBB.1.5 component. Considering that NYC probably played a central role in the emergence of the XBB.1.5 variant, we conducted phylogeographic analysis to investigate the emergence and spread of this variant in the metropolitan area. Our analysis confirms that XBB.1.5 emerged within or near the NYC area and indicates that XBB.1.5 had a diffusion velocity similar to that of the variant Alpha in the same study area. Additionally, the analysis of 2,392 genomes collected in the context of the genomic surveillance program at NYU Langone Health system (NYULH) showed that there was no increased proportion of XBB.1.5, relative to all cocirculating variants, in the boosted compared to unvaccinated individuals. This study provides a comprehensive description of the emergence and dissemination of XBB.1.5.

查看原文本刊更多论文

SARS-CoV-2 XBB.1.5 在纽约的出现和传播

重组 SARS-CoV-2 Omicron XBB.1.5 变体首次在纽约市（NYC）被检测到，并在 2023 年初迅速成为该地区的主要变体。SARS-CoV-2 XBB 亚系中循环变异体的增加促使 Moderna 和辉瑞生物技术公司对 COVID-19 mRNA 疫苗进行了修改。这一更新于 2023 年 9 月中旬实施，包括加入单价 XBB.1.5 成分。考虑到纽约市可能在XBB.1.5变异体的出现中发挥了核心作用，我们进行了系统地理学分析，以调查该变异体在纽约大都会地区的出现和传播情况。我们的分析证实，XBB.1.5 在纽约市内或附近地区出现，并表明 XBB.1.5 的扩散速度与同一研究地区的变异体 Alpha 相似。此外，对纽约大学朗贡卫生系统（NYULH）基因组监测计划中收集的 2392 个基因组进行的分析表明，与未接种疫苗的个体相比，接种过疫苗的个体中 XBB.1.5 的比例相对于所有共循环变体并没有增加。这项研究全面描述了 XBB.1.5 的出现和传播。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Virus Evolution Immunology and Microbiology-Microbiology

CiteScore

10.50

自引率

5.70%

发文量

108

审稿时长

14 weeks

期刊介绍： Virus Evolution is a new Open Access journal focusing on the long-term evolution of viruses, viruses as a model system for studying evolutionary processes, viral molecular epidemiology and environmental virology. The aim of the journal is to provide a forum for original research papers, reviews, commentaries and a venue for in-depth discussion on the topics relevant to virus evolution.