Clinical effect of equol supplementation in the treatment of desquamative gingivitis with 1-year follow-up

IF 1.9 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE
Aki Kawamoto, Naoyuki Sugano, Masako Sakai, Shouhei Ogisawa, Hiroshi Shiratsuchi, Keisuke Seki, Soichiro Manaka, Naoto Yoshinuma, Shuichi Sato
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引用次数: 0

Abstract

Purpose: Desquamative gingivitis (DG) is characterized by desquamative erosion, edematous erythema, and vesicle formation on the gingiva. Because of its prevalence in women during the pre- and postmenopausal period, its potential association with female hormones has been suggested. Equol is a soy isoflavone metabolite with a chemical structure similar to estrogen. Scientific evidence suggests that equol helps in alleviating menopausal symptoms. This study evaluated the clinical effect of a 12-month equol supplementation as a substitute for estrogen to alleviate DG symptoms.

Methods: The study enrolled 16 women with DG who regularly visited Nihon University School of Dentistry Dental Hospital. Urinary equol levels, periodontal tissue examination, O’Leary’s plaque control record, stimulated saliva flow rate, and gingival pain-related questionnaires were evaluated before and after the 12-month daily intake of 10 mg equol supplement.

Results: Equol supplementation led to a statistically significant improvement in bleeding on probing, visual findings, and reductions in the frequency and severity of gingival pain.

Conclusion: Urinary equol testing and equol supplementation may be novel treatment options for female patients with DG.

补充马钱子醇治疗脱屑性牙龈炎的临床效果及 1 年随访
目的:脱屑性牙龈炎(DG)的特征是牙龈上出现脱屑性糜烂、水肿性红斑和囊泡。由于该病多发于绝经前后的女性,因此有人认为它可能与女性荷尔蒙有关。Equol 是一种大豆异黄酮代谢物,其化学结构与雌激素相似。科学证据表明,Equol 有助于缓解更年期症状。本研究评估了补充 12 个月的赤藓糖醇作为雌激素替代品对缓解 DG 症状的临床效果:研究招募了 16 名定期到日本大学齿学部牙科医院就诊的 DG 女性患者。在每天摄入 10 毫克等醇补充剂 12 个月前后,对尿液中的等醇水平、牙周组织检查、O'Leary 牙菌斑控制记录、刺激性唾液流速以及牙龈疼痛相关问卷进行了评估:结果:补充马兜铃醇后,探诊出血、视觉结果以及牙龈疼痛的频率和严重程度均有明显改善:结论:尿中马醇检测和马醇补充剂可能是治疗女性牙龈萎缩症患者的新选择。
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来源期刊
Journal of oral science
Journal of oral science DENTISTRY, ORAL SURGERY & MEDICINE-MATERIALS SCIENCE, BIOMATERIALS
CiteScore
3.80
自引率
0.00%
发文量
58
期刊介绍: Information not localized
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