Ciclosporin‐responsive pyoderma in dogs: A comparison to human pyoderma gangrenosum

IF 0.3 Q4 VETERINARY SCIENCES

Veterinary Record Case Reports Pub Date : 2024-05-10 DOI:10.1002/vrc2.894

Michela De Lucia, Paola Orlandini, Daria Denti, Laura Berto, Giorgia Mezzalira, Andrea Peserico, Anna Belloni Fortina

引用次数: 0

Abstract

We describe 20 cases of canine pyoderma responsive to immunosuppressive treatments and resembling human pyoderma gangrenosum. All dogs presented with a rapidly evolving, focal to multifocal, painful ulcerative dermatitis, non‐responsive to multiple antibiotic and anti‐inflammatory therapies. Elevations of C‐reactive protein (100%), neutrophilia (75%) and fever (25%) were also present. Histopathology showed a severe, ulcerative, superficial to deep, predominantly neutrophilic dermatitis. Bacterial infection was the most challenging differential diagnosis. Resolution of the lesions was obtained within 4–8 weeks in 83% of dogs treated with ciclosporin. Maintenance treatment was required in the majority of the dogs.

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狗的环孢素反应性脓皮病：与人类脓皮病的比较

我们描述了 20 例对免疫抑制治疗有反应且与人类脓皮病相似的犬脓皮病病例。所有病犬均表现为快速发展、局灶性至多发性、疼痛的溃疡性皮炎，对多种抗生素和消炎疗法均无反应。此外，还出现了 C 反应蛋白升高（100%）、中性粒细胞增多（75%）和发热（25%）。组织病理学显示，患者患有严重的溃疡性、浅表至深部、以中性粒细胞为主的皮炎。细菌感染是最具挑战性的鉴别诊断。83%的狗在接受环孢素治疗后 4-8 周内皮损消退。大多数狗需要进行维持治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary Record Case Reports Veterinary-Veterinary (all)

CiteScore

0.50

自引率

33.30%

发文量

266

期刊介绍： Vet Record Case Reports is an online resource that publishes articles in all fields of veterinary medicine and surgery so that veterinary professionals, researchers and others can easily find important information on both common and rare conditions. Articles may be about a single animal, herd, flock or other group of animals managed together. Common cases that present a diagnostic, ethical or management challenge, or that highlight aspects of mechanisms of injury, pharmacology or histopathology are deemed of particular educational value. All articles are peer reviewed and copy edited before publication.