Synthesis of Versatile Aryliodine Synthons by Aryliodonium Rearrangement Reactions

IF 2.8 4区 化学 Q1 CHEMISTRY, ORGANIC
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引用次数: 0

Abstract

The excellent reactivity of diaryliodonium salts has primarily been attributed to the efficient departure of the iodoarene unit, facilitating a variety of arylation reactions. However, one equivalent of iodoarene as a side‐product is a chemical waste in these reactions, which was criticized by chemists for hindering its popularity. Recently, the development of synthetic methodology that preserve the aryl iodine moiety received increasing attention. Oxidative rearrangement reactions involving aryliodonium reagents have significantly addressed the atom‐economic issue, thereby broadening the reaction scope. The resulting intricate aryliodine products are viewed as valuable synthons for the synthesis of natural products, pharmaceutical intermediates and other fine chemicals.

通过芳基碘鎓重排反应合成多功能芳基碘合成物
二芳基碘鎓盐具有出色的反应活性,这主要归功于碘芳烃单元的高效离去,从而促进了各种芳基化反应。然而,在这些反应中,作为副产物的一当量碘芳烃是一种化学废物,化学家们批评这阻碍了碘芳烃的普及。最近,能保留芳基碘分子的合成方法的开发受到越来越多的关注。涉及芳基碘试剂的氧化重排反应极大地解决了原子经济性问题,从而拓宽了反应范围。由此产生的复杂的芳基碘产品被视为合成天然产品、医药中间体和其他精细化学品的宝贵合成物。
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来源期刊
CiteScore
4.70
自引率
3.70%
发文量
372
期刊介绍: Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
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