Application of breathomics in pediatric asthma: a review

IF 3.5 Q2 CHEMISTRY, ANALYTICAL
Lei Chi, Xiaoli Wang, Yuxia Shan, Chonghui Zhu, Ling Leng, Rong Chen, Qing Xie, Zhenze Cui and Minghui Yang
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引用次数: 0

Abstract

Breathomics involves the use of non-invasive methods for diagnosing asthma by analyzing exhaled breath. While significant progress has been made in applying this approach to adult asthma, extending its application to pediatric asthma is crucial due to the increasing concern in this population. This review delineates five potential clinical applications: asthma diagnosis, differential diagnosis of asthma, assessment of asthma control levels, prediction of asthma exacerbation, and asthma phenotyping. Additionally, it highlights the moderate to reasonable predictive accuracy of exhaled breath volatile organic compounds (VOCs) breathomics in childhood asthma. However, it acknowledges that this field is still in its nascent stage of development, with particularly limited data available for Asian populations. Moreover, the identification of VOC biomarkers in pediatric asthma patients remains inconclusive, with varying reports. Therefore, large-scale data collection and standardization are imperative. Refinement and methodological improvements are necessary before integrating breathomics into clinical practice. This article provides clear directions for future research to optimize the clinical applicability of breathomics in evaluating asthma in children.

Abstract Image

Abstract Image

呼吸组学在小儿哮喘中的应用:综述
呼吸组学是一种通过分析呼出的气体来诊断哮喘的非侵入性方法。虽然在将这种方法应用于成人哮喘方面已经取得了重大进展,但将其应用扩展到小儿哮喘至关重要,因为小儿哮喘日益受到关注。本综述阐述了五种潜在的临床应用:哮喘诊断、哮喘鉴别诊断、哮喘控制水平评估、哮喘恶化预测和哮喘表型。此外,该研究还强调了呼出气体挥发性有机化合物(VOCs)呼吸组学对儿童哮喘的预测准确性为中等至合理水平。不过,该研究承认,这一领域仍处于发展的初级阶段,尤其是针对亚洲人群的数据非常有限。此外,儿科哮喘患者体内挥发性有机化合物生物标志物的鉴定仍无定论,报告也不尽相同。因此,大规模的数据收集和标准化工作势在必行。在将呼吸组学应用于临床实践之前,有必要对方法进行完善和改进。本文为未来的研究提供了明确的方向,以优化呼吸组学在儿童哮喘评估中的临床应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.30
自引率
0.00%
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