Interpretation of coagulation laboratory tests for patients on ECMO

IF 2.2 4区医学 Q3 HEMATOLOGY

International Journal of Laboratory Hematology Pub Date : 2024-05-15 DOI:10.1111/ijlh.14308

Simon Davidson

引用次数: 0

Abstract

Extracorporeal membrane oxygenation (ECMO) is a type of circulatory life support for patients with severe lung failure. The use of ECMO has increased worldwide since the pandemic of H1N1 in 2009 and more recently SARS-CoV-2 in 2020 both of which caused severe respiratory failure. ECMO patients experience both increased risk of bleeding and thrombosis. This is due to the pathological insult that damages the lungs, the ECMO circuit, coagulopathy, inflammation and anticoagulation. ECMO presents unique demands on the coagulation laboratory both in tests required to manage the patients and result interpretation. This is a personal opinion of 20 years ECMO experience as a clinical scientist and a short current review of the literature. It will focus on the laboratory coagulation tests used to manage ECMO patients, including different anticoagulants used, testing frequency and interpretation of the results.

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对使用 ECMO 的患者进行凝血实验室检测的解释。

体外膜肺氧合（ECMO）是为严重肺衰竭患者提供的一种循环生命支持。自 2009 年甲型 H1N1 流感和 2020 年 SARS-CoV-2 导致严重呼吸衰竭以来，ECMO 的使用在全球范围内不断增加。ECMO 患者出血和血栓形成的风险都会增加。这是由于病理损伤损害了肺部、ECMO 循环、凝血功能障碍、炎症和抗凝。ECMO 对凝血实验室提出了独特的要求，包括管理患者所需的检测和结果解释。本文是作为一名临床科学家对 20 年 ECMO 经验的个人见解，也是对当前文献的简短回顾。它将重点介绍用于管理 ECMO 患者的实验室凝血测试，包括使用的不同抗凝剂、测试频率和结果解读。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Laboratory Hematology 医学-血液学

CiteScore

4.50

自引率

6.70%

发文量

211

审稿时长

6-12 weeks

期刊介绍： The International Journal of Laboratory Hematology provides a forum for the communication of new developments, research topics and the practice of laboratory haematology. The journal publishes invited reviews, full length original articles, and correspondence. The International Journal of Laboratory Hematology is the official journal of the International Society for Laboratory Hematology, which addresses the following sub-disciplines: cellular analysis, flow cytometry, haemostasis and thrombosis, molecular diagnostics, haematology informatics, haemoglobinopathies, point of care testing, standards and guidelines. The journal was launched in 2006 as the successor to Clinical and Laboratory Hematology, which was first published in 1979. An active and positive editorial policy ensures that work of a high scientific standard is reported, in order to bridge the gap between practical and academic aspects of laboratory haematology.