Rice bran arabinoxylan compound as a natural product for cancer treatment - an evidence-based assessment of the effects and mechanisms.

IF 3.9 3区 医学 Q1 MEDICAL LABORATORY TECHNOLOGY
Pharmaceutical Biology Pub Date : 2024-12-01 Epub Date: 2024-05-15 DOI:10.1080/13880209.2024.2349042
Soo Liang Ooi, Peter S Micalos, Jeanman Kim, Sok Cheon Pak
{"title":"Rice bran arabinoxylan compound as a natural product for cancer treatment - an evidence-based assessment of the effects and mechanisms.","authors":"Soo Liang Ooi, Peter S Micalos, Jeanman Kim, Sok Cheon Pak","doi":"10.1080/13880209.2024.2349042","DOIUrl":null,"url":null,"abstract":"<p><strong>Context: </strong>Rice bran arabinoxylan compound (RBAC) is a natural immunomodulator with anticancer properties.</p><p><strong>Objective: </strong>This study critically evaluates the available evidence on the biological pathways of RBAC and its effects on cancer treatment.</p><p><strong>Methods: </strong>This secondary analysis of a scoping review includes studies evaluating the mechanisms of RBAC on healthy or malignant cells, animal models, or humans for cancer prevention or treatment. Data from randomized controlled trials on survival and quality of life outcomes were subjectd to meta analysis.</p><p><strong>Results: </strong>The evidence synthesis was based on 38 articles. RBAC exhibited antitumor properties by promoting apoptosis and restoring immune function in cancer patients to enhance inflammatory and cytotoxic responses to block tumorigenesis. RBAC works synergistically with chemotherapeutic agents by upregulating drug transport. In a clinical trial, combining RBAC with chemoembolization in treating liver cancer showed improved response, reduced recurrence rates, and prolonged survival. RBAC also augments the endogenous antioxidant system to prevent oxidative stress and protect against radiation side effects. In addition, RBAC has chemoprotective effects. Animals and humans have exhibited reduced toxicity and side effects from chemotherapy. Meta analysis indicates that RBAC treatment increases the survival odds by 4.02-times (95% CI: 1.67, 9.69) in the first year and 2.89-times (95% CI: 1.56, 5.35) in the second year.</p><p><strong>Conclusion: </strong>RBAC is a natural product with immense potential in cancer treatment. Additional research is needed to characterize, quantify, and standardize the active ingredients in RBAC responsible for the anticancer effects. More well-designed, large-scale clinical trials are required to substantiate the treatment efficacies further.</p>","PeriodicalId":19942,"journal":{"name":"Pharmaceutical Biology","volume":"62 1","pages":"367-393"},"PeriodicalIF":3.9000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11097709/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutical Biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/13880209.2024.2349042","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/15 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Context: Rice bran arabinoxylan compound (RBAC) is a natural immunomodulator with anticancer properties.

Objective: This study critically evaluates the available evidence on the biological pathways of RBAC and its effects on cancer treatment.

Methods: This secondary analysis of a scoping review includes studies evaluating the mechanisms of RBAC on healthy or malignant cells, animal models, or humans for cancer prevention or treatment. Data from randomized controlled trials on survival and quality of life outcomes were subjectd to meta analysis.

Results: The evidence synthesis was based on 38 articles. RBAC exhibited antitumor properties by promoting apoptosis and restoring immune function in cancer patients to enhance inflammatory and cytotoxic responses to block tumorigenesis. RBAC works synergistically with chemotherapeutic agents by upregulating drug transport. In a clinical trial, combining RBAC with chemoembolization in treating liver cancer showed improved response, reduced recurrence rates, and prolonged survival. RBAC also augments the endogenous antioxidant system to prevent oxidative stress and protect against radiation side effects. In addition, RBAC has chemoprotective effects. Animals and humans have exhibited reduced toxicity and side effects from chemotherapy. Meta analysis indicates that RBAC treatment increases the survival odds by 4.02-times (95% CI: 1.67, 9.69) in the first year and 2.89-times (95% CI: 1.56, 5.35) in the second year.

Conclusion: RBAC is a natural product with immense potential in cancer treatment. Additional research is needed to characterize, quantify, and standardize the active ingredients in RBAC responsible for the anticancer effects. More well-designed, large-scale clinical trials are required to substantiate the treatment efficacies further.

米糠阿拉伯木聚糖化合物作为治疗癌症的天然产品--基于证据的效果和机制评估。
背景:米糠阿拉伯木聚糖化合物(RBAC)是一种具有抗癌特性的天然免疫调节剂:米糠阿拉伯木聚糖化合物(RBAC)是一种具有抗癌特性的天然免疫调节剂:本研究批判性地评估了有关米糠阿拉伯木聚糖化合物的生物学途径及其对癌症治疗效果的现有证据:这项范围综述的二次分析包括评估 RBAC 对健康或恶性细胞、动物模型或人类预防或治疗癌症的机制的研究。对随机对照试验中有关生存和生活质量结果的数据进行了元分析:证据综述基于 38 篇文章。RBAC 通过促进癌症患者的细胞凋亡和恢复免疫功能来增强炎症反应和细胞毒性反应,从而阻止肿瘤发生,因此具有抗肿瘤特性。RBAC 通过上调药物转运,与化疗药物协同作用。在一项临床试验中,将 RBAC 与化疗栓塞疗法结合起来治疗肝癌,结果显示患者的反应有所改善,复发率降低,生存期延长。RBAC 还能增强内源性抗氧化系统,防止氧化应激,防止辐射副作用。此外,RBAC 还具有化学保护作用。动物和人类的化疗毒性和副作用都有所减轻。Meta 分析表明,RBAC 治疗可使患者第一年的存活率提高 4.02 倍(95% CI:1.67, 9.69),第二年的存活率提高 2.89 倍(95% CI:1.56, 5.35):RBAC是一种天然产品,在癌症治疗方面具有巨大潜力。结论:RBAC 是一种在癌症治疗方面具有巨大潜力的天然产品,还需要更多的研究来确定、量化和标准化 RBAC 中具有抗癌作用的活性成分。还需要进行更多精心设计的大规模临床试验,以进一步证实其治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Pharmaceutical Biology
Pharmaceutical Biology 医学-药学
CiteScore
6.70
自引率
2.60%
发文量
191
审稿时长
1 months
期刊介绍: Pharmaceutical Biology will publish manuscripts describing the discovery, methods for discovery, description, analysis characterization, and production/isolation (including sources and surveys) of biologically-active chemicals or other substances, drugs, pharmaceutical products, or preparations utilized in systems of traditional medicine. Topics may generally encompass any facet of natural product research related to pharmaceutical biology. Papers dealing with agents or topics related to natural product drugs are also appropriate (e.g., semi-synthetic derivatives). Manuscripts will be published as reviews, perspectives, regular research articles, and short communications. The primary criteria for acceptance and publication are scientific rigor and potential to advance the field.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信