Marco Orlandi, Nicola Pranno, Vipul Patel, Piero Papi, Bianca Di Murro, Giorgio Pompa, Antonella Polimeni, Claudio Letizia, Jeanie Suvan, Francesco D'Aiuto
{"title":"Peri-implant diseases and systemic inflammation: A preliminary analysis from a cross-sectional survey of patients with hypertension","authors":"Marco Orlandi, Nicola Pranno, Vipul Patel, Piero Papi, Bianca Di Murro, Giorgio Pompa, Antonella Polimeni, Claudio Letizia, Jeanie Suvan, Francesco D'Aiuto","doi":"10.1002/JPER.21-0338","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>The aim of this study was to investigate the association between peri-implant diseases and systemic inflammation assessed by serum C-reactive protein (CRP) levels in a sample of patients with hypertension.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A total of 151 participants with hypertension were included in a cross-sectional study. The population was divided into six groups according to their peri-implant and periodontal status (healthy controls, mucositis, peri-implantitis, periodontitis, periodontitis and mucositis, periodontitis, and peri-implantitis). Linear, logistic regression, and correlation analyses were performed.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>CRP levels were statistically significantly higher in participants with periodontitis alone (median 3.2 mg/L, interquartile range [IQR] 1.8, <i>p</i> = 0.012), combined with mucositis (3.10 mg/L, IQR 2.35, <i>p</i> < 0.001) or peri-implantitis (2.7 mg/L, IQR 2.53, <i>p</i> = 0.002) when compared to the healthy controls (1 mg/L, IQR 1.2). This association was independent of age, sex, smoking status, and adiposity differences. Participants with periodontitis with and without peri-implant diseases had the greatest odds of exhibiting CRP > 3 mg/L (odds ratio = 7.3, 95% confidence interval 1.6–33.9).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Peri-implant diseases are associated with systemic inflammation, but the nature of the association should be further investigated.</p>\n </section>\n </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.21-0338","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of periodontology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/JPER.21-0338","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Background
The aim of this study was to investigate the association between peri-implant diseases and systemic inflammation assessed by serum C-reactive protein (CRP) levels in a sample of patients with hypertension.
Methods
A total of 151 participants with hypertension were included in a cross-sectional study. The population was divided into six groups according to their peri-implant and periodontal status (healthy controls, mucositis, peri-implantitis, periodontitis, periodontitis and mucositis, periodontitis, and peri-implantitis). Linear, logistic regression, and correlation analyses were performed.
Results
CRP levels were statistically significantly higher in participants with periodontitis alone (median 3.2 mg/L, interquartile range [IQR] 1.8, p = 0.012), combined with mucositis (3.10 mg/L, IQR 2.35, p < 0.001) or peri-implantitis (2.7 mg/L, IQR 2.53, p = 0.002) when compared to the healthy controls (1 mg/L, IQR 1.2). This association was independent of age, sex, smoking status, and adiposity differences. Participants with periodontitis with and without peri-implant diseases had the greatest odds of exhibiting CRP > 3 mg/L (odds ratio = 7.3, 95% confidence interval 1.6–33.9).
Conclusions
Peri-implant diseases are associated with systemic inflammation, but the nature of the association should be further investigated.