Viscoelastic coagulation monitoring parameters in cats with acute arterial thromboembolism

IF 2.1 2区农林科学 Q1 VETERINARY SCIENCES

Journal of Veterinary Internal Medicine Pub Date : 2024-05-15 DOI:10.1111/jvim.17050

Amanda J. Johnson, Elizabeth A. Rozanski, Armelle M. de Laforcade, Claudia Davila, John E. Rush, Julien Guillaumin

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引用次数: 0

Abstract

Background

Hypercoagulability has been documented in cats with cardiac disease. However, hemostatic parameters, including viscoelastic coagulation monitoring (VCM) have not been reported in cats with arterial thromboembolism (ATE).

Hypothesis/Objectives

Compare VCM parameters in cats with acute cardiogenic ATE and in control cats.

Animals

Sixteen cats with ATE and 30 control cats.

Methods

Multicenter university-based prospective study. Cardiogenic ATE was diagnosed based on physical examination and by ultrasonographically-diagnosed left atrial enlargement. Viscoelastic coagulation monitor analysis, CBC, serum biochemistry profile and coagulation profile were performed at admission in cats with ATE. Analysis from healthy control cats was performed using blood collected by direct venipuncture. Our objective was comparison of VCM parameters clot time (CT), clot formation time (CFT), alpha angle (Angle), maximum clot formation (MCF), amplitude at 10 and 20 minutes (A10 and A20, respectively) and clot lysis index at 30 and 45 minutes (LI30 and LI45, respectively) between ATE and control cats.

Results

Cats with ATE had a decreased angle compared to control cats, with a median (range) of 43° (30-48°) compared to 47° (14-59°; P = .01). The parameters A10, A20 and MCF were decreased in ATE cats compared to control cats with a median (range) of 19 units (8–32) compared to 22 units (6–38), 24.5 units (11-40) compared to 29 units (10-47) and 29.5 units (13-44) compared to 33.5 units (14-53), respectively (P = .01, .01 and .01, respectively). The parameters CT, CFT, LI30 and LI45 were similar between groups (P = .22, .09, .62 and .34, respectively).

Conclusions and Clinical Importance

Cats with cardiogenic ATE cats have VCM parameters consistent with hypocoagulability compared with healthy cats.

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急性动脉血栓栓塞猫的粘弹性凝血监测参数。

背景：有记录表明，患有心脏病的猫会出现高凝状态。然而，动脉血栓栓塞症（ATE）猫的止血参数，包括粘弹性凝血监测（VCM）尚未见报道：比较急性心源性 ATE 猫和对照组猫的 VCM 参数：方法：基于大学的多中心前瞻性研究：多中心大学前瞻性研究。心源性 ATE 根据体格检查和超声波诊断的左心房扩大进行诊断。入院时对 ATE 猫进行粘弹性凝血监测分析、全血细胞计数、血清生化分析和凝血分析。通过直接静脉穿刺采集的血液对健康对照组的猫进行了分析。我们的目标是比较 ATE 猫和对照组猫的 VCM 参数凝块时间（CT）、凝块形成时间（CFT）、α 角（Angle）、最大凝块形成（MCF）、10 和 20 分钟时的振幅（分别为 A10 和 A20）以及 30 和 45 分钟时的凝块溶解指数（分别为 LI30 和 LI45）：结果：与对照组相比，ATE 猫的角度有所减小，中位数（范围）为 43°（30-48°），而对照组为 47°（14-59°；P = .01）。与对照组相比，ATE 猫的 A10、A20 和 MCF 参数均有所下降，中位数（范围）分别为 19 个单位（8-32）比 22 个单位（6-38）、24.5 个单位（11-40）比 29 个单位（10-47）和 29.5 个单位（13-44）比 33.5 个单位（14-53）（P = .01、.01 和 .01）。各组之间的 CT、CFT、LI30 和 LI45 参数相似（P = .22、.09、.62 和 .34）：结论和临床意义：与健康猫相比，心源性 ATE 猫的 VCM 参数与低凝状态一致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Veterinary Internal Medicine 农林科学-兽医学

CiteScore

4.50

自引率

11.50%

发文量

243

审稿时长

22 weeks

期刊介绍： The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.