Erosive Tooth Wear, Wine Intake, and Genetic Variation in COMT and MMP2.

IF 2.9 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Caries Research Pub Date : 2024-05-16 DOI:10.1159/000536333

Juliane Rolim de Lavôr, Adriana Mendonça da Silva, Jenny Bogstad Søvik, Aronita Rosenblatt, Aida Mulic, Alexandre Rezende Vieira

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引用次数: 0

Abstract

Introduction: Erosive tooth wear (ETW) is a multifactorial condition of increasing prevalence in the younger population. This study aimed to explore the association between different ETW phenotypes with MMP2 and COMT single-nucleotide variants and selected environmental factors.

Methods: Saliva samples, erosive wear, and dental caries experience data and dietary/behavioral information from 16- to 18-year-old patients (n = 747) were used. Genotypes were obtained, and phenotypes were further analyzed considering diet and behavioral data, using logistic regression as implemented in PLINK, with an alpha of 0.05.

Results: When comparing individuals' ETW-free with those with mild ETW, an association was found with COMT rs6269 (p = 0.02). The comparison between ETW-free individuals with individuals with severe ETW also showed an association with COMT rs6269 under the recessive model (p = 0.03). Logistic regression showed that in the presence of less common alleles of MMP2 rs9923304 and COMT rs6269, ETW was more likely to occur when individuals drank wine. The GG genotype of COMT rs6269 was associated with the presence of lower (p = 0.02) and higher (p = 0.02) caries experience when individuals with ETW only in enamel were compared with individuals with ETW involving dentin.

Conclusion: The results support a role of genes in ETW, with wine consumption being identified as a significant modulator, suggesting that gene-environment interactions may contribute to the development of ETW.

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腐蚀性牙齿磨损、葡萄酒摄入量以及 COMT 和 MMP2 的遗传变异。

简介腐蚀性牙齿磨损（ETW）是一种多因素疾病，在年轻人群中的发病率越来越高。本研究旨在探讨不同的 ETW 表型与 MMP2 和 COMT 单核苷酸变异及特定环境因素之间的关联：方法：采用 16-18 岁患者（n= 747）的唾液样本、侵蚀性磨损和龋齿经验数据以及饮食/行为信息。使用 PLINK 中实现的逻辑回归（α值为 0.05）获得基因型，并考虑饮食和行为数据进一步分析表型：结果：在比较无 ETW 和轻度 ETW 的个体时，发现 COMT rs6269 与 ETW 有关联（p = 0.02）。在隐性模型下，无 ETW 者与重度 ETW 者之间的比较也显示出 COMT rs6269 的相关性（p = 0.03）。逻辑回归结果表明，如果存在 MMP2 rs9923304 和 COMT rs6269 的较少见等位基因，饮用葡萄酒的人更有可能发生 ETW。COMT rs6269的GG基因型与仅在牙釉质发生ETW的人和在牙本质发生ETW的人相比，龋齿发生率较低（p = 0.02）和较高（p = 0.02）：结论：研究结果支持基因在 ETW 中的作用，其中饮用葡萄酒被认为是一个重要的调节因子，这表明基因与环境的相互作用可能会导致腐蚀性牙齿磨损的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Caries Research 医学-牙科与口腔外科

CiteScore

6.30

自引率

7.10%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Caries Research'' publishes epidemiological, clinical and laboratory studies in dental caries, erosion and related dental diseases. Some studies build on the considerable advances already made in caries prevention, e.g. through fluoride application. Some aim to improve understanding of the increasingly important problem of dental erosion and the associated tooth wear process. Others monitor the changing pattern of caries in different populations, explore improved methods of diagnosis or evaluate methods of prevention or treatment. The broad coverage of current research has given the journal an international reputation as an indispensable source for both basic scientists and clinicians engaged in understanding, investigating and preventing dental disease.