Analysis of Influencing Factors and Strategies for Premature Breast Development in Female Children based on Logistic Regression Analysis: A Randomized Double-blind Controlled Clinical Trial.

IF 1.9 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Alternative therapies in health and medicine Pub Date : 2025-01-01

Cui Haijing, Wang Xia, Liu Xinguang, Liu Peng, Du Wenzhong

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引用次数: 0

Abstract

Objective: To investigate and analyze the influencing factors of simple early breast development in girls, to discover the dangers and triggers of PT conversion to ICPP, and the time point of transformation in order to detect and prevent the occurrence of transformation in advance and reduce the incidence of idiopathic central precocious puberty. Ensure children's physical and mental health and normal growth and development.

Methods: A total of 50 children with PT admitted to our hospital from April 2019 to December 2020 were included in the study group, and 50 children with physical examination during the same period were selected as the control group. All children were tested for vitamin D, androstenedione, dehydroepiandrosterone, 17-hydroxyprogesterone, leptin, IGF-I., and IGFBp-3 at 3, 6, 9 and 12 months after the diagnosis of PT.

Results: Vitamin D levels decreased in the child, indicating that vitamin D deficiency was closely related to the age of breast development in ICPP girls and may be related to serum P-FSH, P-LH and E2 levels. Increased levels of IGFBp-3 indicate that these indicators are involved in the onset of ICPP. Children have a higher BMI, watch idol dramas or play mobile games longer, often eat snacks containing preservatives, have a fishy diet, are more irritable and sensitive, and dry stools are also risk factors affecting the early development of simple breasts in girls.

Conclusion: The influencing factors leading to simple, early breast development in girls include vitamin D, androstenedione, dehydroepiandrosterone, 17-hydroxyprogesterone, leptin, IGF-I., IGFBp-3, and should be combined with the progression of breast Tanner staging (complete regression, recurrent, and persistent), height growth rate, bone age, Uterine and ovarian B ultrasound, sex hormones, etc., warn of the conversion of PT to ICPP, and ensure children's physical and mental health and normal growth and development.

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基于逻辑回归分析的女性儿童乳房发育过早的影响因素和策略分析：随机双盲对照临床试验。

目的调查分析女孩单纯性乳房早发育的影响因素，发现PT向ICPP转化的危害和诱因，以及转化的时间点，以便提前发现和预防转化的发生，降低特发性中枢性性早熟的发病率。确保儿童的身心健康和正常生长发育：将我院于2019年4月-2020年12月收治的PT患儿共50例纳入研究组，选取同期体检患儿50例作为对照组。所有患儿在确诊PT后的3、6、9、12个月分别检测维生素D、雄烯二酮、脱氢表雄酮、17-羟孕酮、瘦素、IGF-I、IGFBp-3：结果：患儿的维生素D水平下降，表明维生素D缺乏与ICPP女孩的乳房发育年龄密切相关，并可能与血清P-FSH、P-LH和E2水平有关。IGFBp-3 水平的升高表明这些指标与 ICPP 的发病有关。儿童的体重指数（BMI）较高、看偶像剧或玩手机游戏的时间较长、常吃含防腐剂的零食、饮食偏腥、易怒敏感、大便干燥等也是影响女孩单纯性乳房早发育的危险因素：导致女孩单纯性乳房发育过早的影响因素包括维生素 D、雄烯二酮、脱氢表雄酮、17-羟孕酮、瘦素、IGF-I、IGFBp-3，并应结合乳房Tanner分期进展（完全消退、复发性、持续性）、身高增长率、骨龄、子宫卵巢B超、性激素等，警惕PT向ICPP的转化，确保儿童身心健康和正常生长发育。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alternative therapies in health and medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

0.90

自引率

0.00%

发文量

219

期刊介绍： Launched in 1995, Alternative Therapies in Health and Medicine has a mission to promote the art and science of integrative medicine and a responsibility to improve public health. We strive to maintain the highest standards of ethical medical journalism independent of special interests that is timely, accurate, and a pleasure to read. We publish original, peer-reviewed scientific articles that provide health care providers with continuing education to promote health, prevent illness, and treat disease. Alternative Therapies in Health and Medicine was the first journal in this field to be indexed in the National Library of Medicine. In 2006, 2007, and 2008, ATHM had the highest impact factor ranking of any independently published peer-reviewed CAM journal in the United States—meaning that its research articles were cited more frequently than any other journal’s in the field. Alternative Therapies in Health and Medicine does not endorse any particular system or method but promotes the evaluation and appropriate use of all effective therapeutic approaches. Each issue contains a variety of disciplined inquiry methods, from case reports to original scientific research to systematic reviews. The editors encourage the integration of evidence-based emerging therapies with conventional medical practices by licensed health care providers in a way that promotes a comprehensive approach to health care that is focused on wellness, prevention, and healing. Alternative Therapies in Health and Medicine hopes to inform all licensed health care practitioners about developments in fields other than their own and to foster an ongoing debate about the scientific, clinical, historical, legal, political, and cultural issues that affect all of health care.