Lifestyle-based subtypes of childhood obesity and their association with cardiometabolic factors: A cluster analysis

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2024-05-15 DOI:10.1111/ijpo.13127

Jia-Shuan Huang, Rema Ramakrishnan, Quan-Zhen Liu, Cheng-Rui Wang, Song-Ying Shen, Ming-Xi Huang, Xue-Ling Wei, Xiu Qiu, Jian-Rong He

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引用次数: 0

Abstract

Background

Lifestyle factors play an important role in the development and management of childhood obesity and its related cardiometabolic complications.

Objective/Methods

We aimed to explore childhood obesity subtypes based on lifestyle factors and examine their association with cardiometabolic health. We included 1550 children with obesity from the National Health and Nutrition Examination Survey. Cluster analysis identified obesity subtypes based on four lifestyle factors (physical activity, diet quality, sedentary time and smoking). Multiple linear regression assessed their association with cardiometabolic factors.

Results

Five subtypes of childhood obesity were identified: unhealthy subtype (n = 571; 36.8%), physically active subtype (n = 185; 21.1%), healthy diet subtype (n = 404; 26.1%), smoking subtype (n = 125; 8.1%) and non-sedentary subtype (n = 265; 17.1%). Compared with the unhealthy subtype, the physically active subtype had lower insulin and HOMA-IR levels, and smoking subtype was associated with lower HDL levels. When compared with children with normal weight, all obesity subtypes had worse cardiometabolic profile, except the physically active subtype who had similar DBP, HbA1c and TC levels; smoking subtype who had similar TC levels; and healthy diet and non-sedentary subtypes who had similar DBP levels.

Conclusion

Children of different lifestyle-based obesity subtypes might have different cardiometabolic risks. Our new classification system might help personalize assessment of childhood obesity.

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基于生活方式的儿童肥胖亚型及其与心脏代谢因素的关系：聚类分析

背景：生活方式因素在儿童肥胖症及其相关心脏代谢并发症的发展和管理中发挥着重要作用：我们旨在探索基于生活方式因素的儿童肥胖亚型，并研究其与心脏代谢健康的关系。我们从全国健康与营养调查中纳入了 1550 名肥胖儿童。聚类分析根据四种生活方式因素（体育锻炼、饮食质量、久坐时间和吸烟）确定了肥胖亚型。多元线性回归评估了这些亚型与心脏代谢因素的关系：结果：发现了五种儿童肥胖亚型：不健康亚型（n = 571；36.8%）、体力活动亚型（n = 185；21.1%）、健康饮食亚型（n = 404；26.1%）、吸烟亚型（n = 125；8.1%）和非久坐亚型（n = 265；17.1%）。与不健康亚型相比，体力活动亚型的胰岛素和HOMA-IR水平较低，而吸烟亚型的高密度脂蛋白水平较低。与体重正常的儿童相比，所有肥胖亚型的心血管代谢状况都较差，只有体力活动亚型的DBP、HbA1c和TC水平相似；吸烟亚型的TC水平相似；健康饮食亚型和非久坐亚型的DBP水平相似：结论：不同生活方式的肥胖亚型儿童可能有不同的心脏代谢风险。我们的新分类系统可能有助于对儿童肥胖进行个性化评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.