Nanoprobe for blood–brain barrier changes

IF 28.2 1区医学 Q1 CLINICAL NEUROLOGY

Nature Reviews Neurology Pub Date : 2024-05-14 DOI:10.1038/s41582-024-00971-x

Lisa Kiani

引用次数: 0

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检测血脑屏障变化的纳米探针

最新研究表明，用纳米粒子探针标记层粘连蛋白可通过磁共振成像评估神经炎症引起的血脑屏障（BBB）变化。以氧化铁为基础的纳米粒子用肽-88进行了载体化，肽-88能在炎症条件下与层粘连蛋白特异性结合。对自身免疫性脑脊髓炎（EAE）小鼠模型和对照组小鼠的核磁共振成像进行比较后发现，注射纳米探针后，EAE小鼠的对比度增加，这表明该探针可用于检测血脑屏障通透性的增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Neurology 医学-临床神经学

CiteScore

29.90

自引率

0.80%

发文量

138

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Neurology aims to be the premier source of reviews and commentaries for the scientific and clinical communities we serve. We want to provide an unparalleled service to authors, referees, and readers, and we work hard to maximize the usefulness and impact of each article. The journal publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians working in the field of neurology. Our broad scope ensures that the work we publish reaches the widest possible audience. Our articles are authoritative, accessible, and enhanced with clearly understandable figures, tables, and other display items. This page gives more detail about the aims and scope of the journal.