Ankle movement alterations during gait in children with acute lymphoblastic leukemia with suspected peripheral mononeuropathy. A cross-sectional study

IF 1.4 3区医学 Q4 ENGINEERING, BIOMEDICAL

Clinical Biomechanics Pub Date : 2024-05-01 DOI:10.1016/j.clinbiomech.2024.106261

José Luis Alaniz-Arcos , Xochiquetzalli Tejeda Castellanos , Carlos Maximiliano Sánchez Medina , Horacio Márquez González , Ma Elena Ortiz Cornejo , Juliette Marie Brito Suárez , Claudia Gutiérrez Camacho

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引用次数: 0

Abstract

Background

Peripheral neuropathy due to chemotherapeutic drugs causes alterations in ankle movement during gait. This study aimed to describe the spatiotemporal parameters and ankle kinematics during gait in schoolchildren with acute lymphoblastic leukemia with clinically suspected peripheral neuropathy.

Methods

In children with acute lymphoblastic leukemia in the maintenance phase, we calculated spatiotemporal and kinematic parameters of the ankle during gait using Kinovea® software. Furthermore, we identified alterations in the parameters obtained considering the values of the normality data from a stereophotogrammetry system as the reference values. Finally, we represented the kinematic parameters of the ankles calculated with Kinovea® compared to the normality values of the stereophotogrammetry.

Findings

We evaluated 25 schoolchildren; 13 were male (52.0%) with a median age of 88.0months and a median of 60.0 weeks in the maintenance phase, and 54.8% were classified as standard risk. Spatiotemporal parameters: cadence (steps/min), bilateral step length (m), and average gait speed (m/s) in ALL children were significantly lower than reference values (p < 0.001). Except for right mid-stance and bilateral foot strike, initial swing showed that both ankles maintained plantar flexion values during gait, significantly lower in ALL patients (p < 0.05).

Interpretation

We identified spatiotemporal and kinematics alterations in schoolchildren with acute lymphoblastic leukemia during all phases of the gait suggestive of alteration in ankle muscles during movement, probably due to peripheral neuropathy; nevertheless, our results should be taken with caution until the accuracy and reliability of Kinovea® software as a diagnostic test compared to the stereophotogrammetric system in children with ALL and healthy peers is proven.

查看原文本刊更多论文

怀疑患有外周单神经病的急性淋巴细胞白血病患儿在步态过程中的踝关节运动变化。横断面研究

背景化疗药物引起的周围神经病变会导致步态时踝关节运动的改变。本研究旨在描述临床怀疑患有周围神经病变的急性淋巴细胞白血病学龄儿童在步态过程中的时空参数和踝关节运动学参数。方法在处于维持期的急性淋巴细胞白血病儿童中，我们使用 Kinovea® 软件计算了步态过程中踝关节的时空参数和运动学参数。此外，我们还以立体摄影测量系统的正常数据值为参考值，确定了参数的变化情况。最后，我们将 Kinovea® 计算出的踝关节运动学参数与立体摄影测量的正常值进行了比较。研究结果我们对 25 名学童进行了评估，其中 13 名为男性（52.0%），年龄中位数为 88.0 个月，处于维持阶段的时间中位数为 60.0 周，54.8% 被归类为标准风险。ALL患儿的时空参数：步幅（步/分钟）、双侧步长（米）和平均步速（米/秒）均显著低于参考值（p <0.001）。除了右侧中段站立和双侧脚掌着地外，初始摆动显示双侧踝关节在步态过程中保持跖屈值，而ALL患者的跖屈值明显较低（p <0.05）。我们在急性淋巴细胞白血病学童步态的各个阶段都发现了时空和运动学的改变，这表明踝关节肌肉在运动过程中发生了改变，可能是由于周围神经病变引起的；然而，在Kinovea®软件作为诊断测试与立体摄影测量系统相比，对ALL患儿和健康儿童的准确性和可靠性得到证实之前，我们的结果应谨慎对待。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Biomechanics 医学-工程：生物医学

CiteScore

3.30

自引率

5.60%

发文量

189

审稿时长

12.3 weeks

期刊介绍： Clinical Biomechanics is an international multidisciplinary journal of biomechanics with a focus on medical and clinical applications of new knowledge in the field. The science of biomechanics helps explain the causes of cell, tissue, organ and body system disorders, and supports clinicians in the diagnosis, prognosis and evaluation of treatment methods and technologies. Clinical Biomechanics aims to strengthen the links between laboratory and clinic by publishing cutting-edge biomechanics research which helps to explain the causes of injury and disease, and which provides evidence contributing to improved clinical management. A rigorous peer review system is employed and every attempt is made to process and publish top-quality papers promptly. Clinical Biomechanics explores all facets of body system, organ, tissue and cell biomechanics, with an emphasis on medical and clinical applications of the basic science aspects. The role of basic science is therefore recognized in a medical or clinical context. The readership of the journal closely reflects its multi-disciplinary contents, being a balance of scientists, engineers and clinicians. The contents are in the form of research papers, brief reports, review papers and correspondence, whilst special interest issues and supplements are published from time to time. Disciplines covered include biomechanics and mechanobiology at all scales, bioengineering and use of tissue engineering and biomaterials for clinical applications, biophysics, as well as biomechanical aspects of medical robotics, ergonomics, physical and occupational therapeutics and rehabilitation.