Lycopene supplement mitigates polystyrene microplastics (PS-MPs)-induced reproductive alteration in rats via modulation of steroidogenic enzymes, inhibition of apoptosis and oxido-inflammatory reaction

IF 1.2 4区 综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES
Oyovwi Mega Obukohwo , Ojetola A. Abodunrin , Ohwin Peggy Ejiro , Rotu A. Rume , Tesi P. Edesiri
{"title":"Lycopene supplement mitigates polystyrene microplastics (PS-MPs)-induced reproductive alteration in rats via modulation of steroidogenic enzymes, inhibition of apoptosis and oxido-inflammatory reaction","authors":"Oyovwi Mega Obukohwo ,&nbsp;Ojetola A. Abodunrin ,&nbsp;Ohwin Peggy Ejiro ,&nbsp;Rotu A. Rume ,&nbsp;Tesi P. Edesiri","doi":"10.1016/j.kjs.2024.100244","DOIUrl":null,"url":null,"abstract":"<div><p>Increasing levels of polystyrene microplastics (PS-MPs) in the environment poses huge global health threat. Prolonged exposure to PS-MPs results in both male and female infertility, with a deleterious effect on reproductive health. In rats, the disruptive effects of chemotoxicants have been countered by lycopene (LYC). This study examined the protective benefits of lycopene (LYC) against spermatological damage and hormonal alterations brought on by polystyrene microplastics (PS-MPs) in male rats. Twenty Wistar rats were split into four groups of five rats, each consisting of: the control group, the PSMPs treatment group, the PS-MPs + LYC co-treatment group, and the LYC supplementation group. Severe testicular histological damage was seen to have resulted from exposure to PS-MPs. The PS-MPs treatment dramatically reduced the antioxidant enzyme activities while raising the levels of ROS and MDA, thus reducing sperm progressive motility. Also, spermatological damage and hormonal alterations brought on by polystyrene microplastics (PS-MPs) were also prevented by the effects of lycopene (LYC). In conclusion, LYC supplementation has the ability to reduce the harmful effects of PS-MPs on the male reproductive system. Accordingly, LYC prevented PS-MPs-induced spermatological damage and reproductive hormonal changes in rats via its anti-oxidant, androgenic, anti-apoptotic, anti-inflammatory properties.</p></div>","PeriodicalId":17848,"journal":{"name":"Kuwait Journal of Science","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2307410824000695/pdfft?md5=fabdf03f2e74c00efddf7996058a48b6&pid=1-s2.0-S2307410824000695-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Kuwait Journal of Science","FirstCategoryId":"103","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2307410824000695","RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Increasing levels of polystyrene microplastics (PS-MPs) in the environment poses huge global health threat. Prolonged exposure to PS-MPs results in both male and female infertility, with a deleterious effect on reproductive health. In rats, the disruptive effects of chemotoxicants have been countered by lycopene (LYC). This study examined the protective benefits of lycopene (LYC) against spermatological damage and hormonal alterations brought on by polystyrene microplastics (PS-MPs) in male rats. Twenty Wistar rats were split into four groups of five rats, each consisting of: the control group, the PSMPs treatment group, the PS-MPs + LYC co-treatment group, and the LYC supplementation group. Severe testicular histological damage was seen to have resulted from exposure to PS-MPs. The PS-MPs treatment dramatically reduced the antioxidant enzyme activities while raising the levels of ROS and MDA, thus reducing sperm progressive motility. Also, spermatological damage and hormonal alterations brought on by polystyrene microplastics (PS-MPs) were also prevented by the effects of lycopene (LYC). In conclusion, LYC supplementation has the ability to reduce the harmful effects of PS-MPs on the male reproductive system. Accordingly, LYC prevented PS-MPs-induced spermatological damage and reproductive hormonal changes in rats via its anti-oxidant, androgenic, anti-apoptotic, anti-inflammatory properties.

通过调节类固醇生成酶、抑制细胞凋亡和氧化-炎症反应,补充番茄红素可减轻聚苯乙烯微塑料(PS-MPs)诱发的大鼠生殖系统改变
环境中聚苯乙烯微塑料(PS-MPs)含量的增加对全球健康构成了巨大威胁。长期接触 PS-MPs 会导致男性和女性不育,并对生殖健康产生有害影响。在大鼠身上,番茄红素(LYC)可以抵消化学毒物的破坏性影响。本研究考察了番茄红素(LYC)对雄性大鼠精子损伤和聚苯乙烯微塑料(PS-MPs)引起的激素变化的保护作用。20 只 Wistar 大鼠被分成四组,每组 5 只,包括:对照组、PS-MPs 处理组、PS-MPs + LYC 联合处理组和补充 LYC 组。暴露于 PS-MPs 会导致睾丸组织学严重受损。PS-MPs 处理显著降低了抗氧化酶的活性,同时提高了 ROS 和 MDA 的水平,从而降低了精子的运动能力。此外,番茄红素(LYC)还能防止聚苯乙烯微塑料(PS-MPs)对精子造成的损伤和激素变化。总之,补充 LYC 能够减少 PS-MPs 对男性生殖系统的危害。因此,LYC 可通过其抗氧化、雄激素、抗凋亡和抗炎特性,防止 PS-MPs 引发的大鼠精子损伤和生殖激素变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Kuwait Journal of Science
Kuwait Journal of Science MULTIDISCIPLINARY SCIENCES-
CiteScore
1.60
自引率
28.60%
发文量
132
期刊介绍: Kuwait Journal of Science (KJS) is indexed and abstracted by major publishing houses such as Chemical Abstract, Science Citation Index, Current contents, Mathematics Abstract, Micribiological Abstracts etc. KJS publishes peer-review articles in various fields of Science including Mathematics, Computer Science, Physics, Statistics, Biology, Chemistry and Earth & Environmental Sciences. In addition, it also aims to bring the results of scientific research carried out under a variety of intellectual traditions and organizations to the attention of specialized scholarly readership. As such, the publisher expects the submission of original manuscripts which contain analysis and solutions about important theoretical, empirical and normative issues.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信