Association of lifestyles and multimorbidity with mortality among individuals aged 60 years or older: Two prospective cohort studies

IF 3.6 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Ssm-Population Health Pub Date : 2024-05-02 DOI:10.1016/j.ssmph.2024.101673

Jianfeng Zhong , Lianhong Chen , Chengping Li , Jing Li , Yingying Niu , Xuerui Bai , Huiyan Wen , Zhiquan Diao , Haoyu Yan , Miao Xu , Wenqi Huang , Zhitong Xu , Xiaofeng Liang , Dan Liu

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引用次数: 0

Abstract

Lifestyles are associated with all-cause mortality, yet limited research has explored the association in the elderly population with multimorbidity. We aim to investigate the impact of adopting a healthy lifestyle on reducing the risk of all-cause mortality in older individuals with or without multimorbidity in both China and UK. This prospective study included 29,451 and 173,503 older adults aged 60 and over from Chinese Longitudinal Healthy Longevity Survey (CLHLS) and UK Biobank. Lifestyles and multimorbidity were categorized into three groups, respectively. Cox proportional hazards regression was used to estimate the Hazard Ratios (HRs), 95% confidence intervals (95% CIs), and dose-response for all-cause mortality in relation to lifestyles and multimorbidity, as well as the combination of both factors. During a mean follow-up period of 4.7 years in CLHLS and 12.14 years in UK Biobank, we observed 21,540 and 20,720 deaths, respectively. For participants with two or more conditions, compared to those with an unhealthy lifestyle, adopting a healthy lifestyle was associated with a 27%–41% and 22%–42% reduction in mortality risk in the CLHLS and UK Biobank, respectively; Similarly, for individuals without multimorbidity, this reduction ranged from 18% to 41%. Among participants with multimorbidity, individuals with an unhealthy lifestyle had a higher mortality risk compared to those maintaining a healthy lifestyle, with HRs of 1.15 (95% CI: 1.00, 1.32) and 1.27 (95% CI: 1.16, 1.39) for two conditions, and 1.24 (95% CI: 1.06, 1.45) and 1.73 (95% CI: 1.56, 1.91) for three or more conditions in CLHLS and UK Biobank, respectively. Adherence to a healthy lifestyle can yield comparable mortality benefits for older individuals, regardless of their multimorbidity status. Furthermore, maintaining a healthy lifestyle can alleviate the mortality risks linked to a higher number of diseases.

查看原文本刊更多论文

生活方式和多病症与 60 岁及以上人群死亡率的关系：两项前瞻性队列研究

生活方式与全因死亡率有关，但对多病老年人群生活方式与全因死亡率关系的研究还很有限。我们旨在调查在中国和英国，采用健康的生活方式对降低患有或不患有多病的老年人全因死亡风险的影响。这项前瞻性研究包括来自中国健康长寿纵向调查（CLHLS）和英国生物库的 29,451 名和 173,503 名 60 岁及以上老年人。研究分别将生活方式和多病症分为三组。采用 Cox 比例危险度回归法估算生活方式和多病症以及这两种因素组合的全因死亡率的危险度比（HRs）、95% 置信区间（95% CIs）和剂量反应。在 CLHLS 平均 4.7 年的随访期和 UK Biobank 平均 12.14 年的随访期中，我们分别观察到 21,540 例和 20,720 例死亡。对于患有两种或两种以上疾病的参与者来说，与那些生活方式不健康的人相比，在 CLHLS 和英国生物样本库中，采用健康的生活方式可使死亡风险分别降低 27%-41% 和 22%-42%；同样，对于没有多重疾病的人来说，这种降低幅度从 18% 到 41% 不等。在患有多种疾病的参与者中，与保持健康生活方式的人相比，生活方式不健康的人的死亡风险更高，在 CLHLS 和英国生物库中，患有两种疾病的 HR 分别为 1.15（95% CI：1.00，1.32）和 1.27（95% CI：1.16，1.39），患有三种或三种以上疾病的 HR 分别为 1.24（95% CI：1.06，1.45）和 1.73（95% CI：1.56，1.91）。坚持健康的生活方式可为老年人带来类似的死亡率益处，无论其是否患有多种疾病。此外，保持健康的生活方式可以降低与较多疾病相关的死亡风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ssm-Population Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

6.50

自引率

2.10%

发文量

298

审稿时长

101 days

期刊介绍： SSM - Population Health. The new online only, open access, peer reviewed journal in all areas relating Social Science research to population health. SSM - Population Health shares the same Editors-in Chief and general approach to manuscripts as its sister journal, Social Science & Medicine. The journal takes a broad approach to the field especially welcoming interdisciplinary papers from across the Social Sciences and allied areas. SSM - Population Health offers an alternative outlet for work which might not be considered, or is classed as ''out of scope'' elsewhere, and prioritizes fast peer review and publication to the benefit of authors and readers. The journal welcomes all types of paper from traditional primary research articles, replication studies, short communications, methodological studies, instrument validation, opinion pieces, literature reviews, etc. SSM - Population Health also offers the opportunity to publish special issues or sections to reflect current interest and research in topical or developing areas. The journal fully supports authors wanting to present their research in an innovative fashion though the use of multimedia formats.