Gut microbial genomes with paired isolates from China illustrate probiotic and cardiometabolic effects.

IF 11.1 Q1 CELL BIOLOGY
Cell genomics Pub Date : 2024-06-12 Epub Date: 2024-05-12 DOI:10.1016/j.xgen.2024.100559
Pan Huang, Quanbin Dong, Yifeng Wang, Yunfan Tian, Shunhe Wang, Chengcheng Zhang, Leilei Yu, Fengwei Tian, Xiaoxiang Gao, Hang Guo, Shanrong Yi, Mingyang Li, Yang Liu, Qingsong Zhang, Wenwei Lu, Gang Wang, Bo Yang, Shumao Cui, Dongxu Hua, Xiuchao Wang, Yuwen Jiao, Lu Liu, Qiufeng Deng, Beining Ma, Tingting Wu, Huayiyang Zou, Jing Shi, Haifeng Zhang, Daming Fan, Yanhui Sheng, Jianxin Zhao, Liming Tang, Hao Zhang, Wei Sun, Wei Chen, Xiangqing Kong, Lianmin Chen, Qixiao Zhai
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引用次数: 0

Abstract

The gut microbiome displays genetic differences among populations, and characterization of the genomic landscape of the gut microbiome in China remains limited. Here, we present the Chinese Gut Microbial Reference (CGMR) set, comprising 101,060 high-quality metagenomic assembled genomes (MAGs) of 3,707 nonredundant species from 3,234 fecal samples across primarily rural Chinese locations, 1,376 live isolates mainly from lactic acid bacteria, and 987 novel species relative to worldwide databases. We observed region-specific coexisting MAGs and MAGs with probiotic and cardiometabolic functionalities. Preliminary mouse experiments suggest a probiotic effect of two Faecalibacillus intestinalis isolates in alleviating constipation, cardiometabolic influences of three Bacteroides fragilis_A isolates in obesity, and isolates from the genera Parabacteroides and Lactobacillus in host lipid metabolism. Our study expands the current microbial genomes with paired isolates and demonstrates potential host effects, contributing to the mechanistic understanding of host-microbe interactions.

中国成对分离的肠道微生物基因组说明益生菌和心脏代谢的影响。
肠道微生物组在不同人群中存在遗传差异,而中国肠道微生物组的基因组特征描述仍然有限。在这里,我们展示了中国肠道微生物参考文献集(CGMR),其中包括来自中国主要农村地区 3,234 份粪便样本的 101,060 个高质量元基因组组装基因组(MAGs),包含 3,707 个非冗余物种,1,376 个主要来自乳酸菌的活体分离物,以及相对于全球数据库的 987 个新物种。我们观察到了特定区域共存的 MAGs 以及具有益生菌和心脏代谢功能的 MAGs。初步的小鼠实验表明,两种肠道粪杆菌分离物具有缓解便秘的益生作用,三种脆弱乳杆菌分离物对肥胖症具有心脏代谢影响,副乳杆菌属和乳酸杆菌属分离物对宿主的脂质代谢具有影响。我们的研究扩大了目前微生物基因组中成对分离物的范围,并展示了对宿主的潜在影响,有助于从机理上理解宿主与微生物之间的相互作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
7.10
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