Advancements and Future Directions in Prevention Based on Evaluation for Individuals With Clinical High Risk of Psychosis: Insights From the SHARP Study.

IF 5.3 1区医学 Q1 PSYCHIATRY

Schizophrenia Bulletin Pub Date : 2025-03-14 DOI:10.1093/schbul/sbae066

TianHong Zhang, LiHua Xu, YanYan Wei, HuiRu Cui, XiaoChen Tang, YeGang Hu, YingYing Tang, ZiXuan Wang, HaiChun Liu, Tao Chen, ChunBo Li, JiJun Wang

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引用次数: 0

Abstract

Background and hypothesis: This review examines the evolution and future prospects of prevention based on evaluation (PBE) for individuals at clinical high risk (CHR) of psychosis, drawing insights from the SHARP (Shanghai At Risk for Psychosis) study. It aims to assess the effectiveness of non-pharmacological interventions in preventing psychosis onset among CHR individuals.

Study design: The review provides an overview of the developmental history of the SHARP study and its contributions to understanding the needs of CHR individuals. It explores the limitations of traditional antipsychotic approaches and introduces PBE as a promising framework for intervention.

Study results: Three key interventions implemented by the SHARP team are discussed: nutritional supplementation based on niacin skin response blunting, precision transcranial magnetic stimulation targeting cognitive and brain functional abnormalities, and cognitive behavioral therapy for psychotic symptoms addressing symptomatology and impaired insight characteristics. Each intervention is evaluated within the context of PBE, emphasizing the potential for tailored approaches to CHR individuals.

Conclusions: The review highlights the strengths and clinical applications of the discussed interventions, underscoring their potential to revolutionize preventive care for CHR individuals. It also provides insights into future directions for PBE in CHR populations, including efforts to expand evaluation techniques and enhance precision in interventions.

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基于对临床高危精神病患者评估的预防措施的进展和未来方向：SHARP 研究的启示。

背景与假设：本综述从上海高危人群研究（SHARP）中汲取灵感，探讨了针对临床高危人群（CHR）的精神病预防评估（PBE）的演变和未来前景。研究旨在评估非药物干预措施在预防临床高危人群中精神病发病方面的有效性：研究设计：综述概述了 SHARP 研究的发展历程及其对了解中国高危人群需求的贡献。研究结果：研究结果：讨论了SHARP团队实施的三项关键干预措施：基于烟酸的皮肤反应钝化营养补充、针对认知和大脑功能异常的精准经颅磁刺激，以及针对症状和洞察力受损特征的精神病症状认知行为疗法。每种干预方法都在 "心理健康教育 "的背景下进行了评估，强调了为慢性精神障碍患者量身定制方法的潜力：本综述强调了所讨论的干预措施的优势和临床应用，强调了这些干预措施彻底改变慢性精神障碍患者预防保健的潜力。综述还深入探讨了针对慢性病患者的预防性保健的未来发展方向，包括努力扩展评估技术和提高干预措施的精确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Schizophrenia Bulletin 医学-精神病学

CiteScore

11.40

自引率

6.10%

发文量

163

审稿时长

4-8 weeks

期刊介绍： Schizophrenia Bulletin seeks to review recent developments and empirically based hypotheses regarding the etiology and treatment of schizophrenia. We view the field as broad and deep, and will publish new knowledge ranging from the molecular basis to social and cultural factors. We will give new emphasis to translational reports which simultaneously highlight basic neurobiological mechanisms and clinical manifestations. Some of the Bulletin content is invited as special features or manuscripts organized as a theme by special guest editors. Most pages of the Bulletin are devoted to unsolicited manuscripts of high quality that report original data or where we can provide a special venue for a major study or workshop report. Supplement issues are sometimes provided for manuscripts reporting from a recent conference.