Anesthetic management with remimazolam for a patient with hereditary angioedema:a case report.

IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2024-01-01 DOI:10.2152/jmi.71.184

Kenshiro Kido, Takahiro Kato, Satoshi Kamiya, Shiho Satomi, Yukari Toyota, Takashi Kondo, Yasuo M Tsutsumi

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Abstract

Background: Hereditary angioedema (HAE), a genetic disorder caused by C1-inhibitor deficiency or dysfunction, may cause mucosal edema in the upper airway during tracheal intubation and extubation.

Case report: A 57-year-old man with HAE and a history of laryngeal edema, scheduled to undergo cervical laminoplasty under general anesthesia. General anesthesia was induced by continuous injection of remimazolam and remifentanil, during which manual mask ventilation and intubation were performed without difficulty. The patient was extubated under deep anesthesia. After emergence from general anesthesia, he had no significant upper airway edema and was treated with a C1-inhibitor seven hours post-surgery because of slight tongue swelling. No additional airway edema was observed, and the patient was discharged from the intensive care unit the following day.

Conclusions: Deep anesthesia tracheal extubation with remimazolam may be effective in preventing upper airway edema during anesthetic management in patients with HAE. J. Med. Invest. 71 : 184-186, February, 2024.

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使用雷马唑仑对遗传性血管性水肿患者进行麻醉处理：病例报告。

背景：遗传性血管性水肿（HAE）是一种由 C1 抑制剂缺乏或功能障碍引起的遗传性疾病，可能导致气管插管和拔管时上气道粘膜水肿：一名患有 HAE 并有喉水肿病史的 57 岁男子计划在全身麻醉下接受颈椎板层成形术。持续注射雷马唑仑和瑞芬太尼诱导全身麻醉，期间顺利进行了人工面罩通气和插管。患者在深麻醉状态下拔管。从全身麻醉中苏醒后，他的上气道没有明显水肿，术后七小时，由于舌头轻微肿胀，他接受了 C1 抑制剂治疗。术后 7 小时，患者因舌头轻微肿胀而接受了 C1 抑制剂治疗，术后未再出现气道水肿，次日患者从重症监护室出院：结论：使用雷马唑仑进行深麻醉气管拔管可有效防止 HAE 患者在麻醉过程中出现上气道水肿。J. Med.Invest.71 : 184-186, February, 2024.

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来源期刊

JOURNAL OF MEDICAL INVESTIGATION MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

1.20

自引率

0.00%

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