Scoring system to predict positive peritoneal cytology in patients with resectable and borderline resectable pancreatic cancer

IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Tomohiro Yoshimura, Atsushi Shimizu, Yuji Kitahata, Hideki Motobayashi, Masatoshi Sato, Kyohei Matsumoto, Masaki Ueno, Shinya Hayami, Ken-ichi Okada, Manabu Kawai
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Abstract

Background

The aim of this study was to evaluate factors to predict positive peritoneal cytology, whcih would determine the indication for staging laparoscopy in pancreatic cancer.

Methods

A total of 430 patients that underwent pancreatectomy for resectable and borderline resectable pancreatic cancer were retrospectively reviewed.

Results

Among 430 patients, 36 had positive cytology (8.4%). Median survival time in negative cytology was 24.7 months, compared with 15.1 months in positive cytology (p = .004). Factors to predict positive cytology in pancreatic cancer according to multivariate analysis were tumor location (body, tail; OR 2.66; 95% CI: 1.21–5.85; p = .015), tumor size ≥30 mm (OR 2.95; 95% CI: 1.35–6.47; p = .007) and radiographic other-organ invasion (HR 2.79; 95% CI: 1.01–7.67; p = .047). Patients were scored 0 to 3 corresponding with these factors. Rates of positive cytology increases in each score were: score 0: 2.9%, score 1: 6.7%, score 2: 18.3%, score 3: 36.8%.

Conclusions

Tumor location (body or tail), tumor size ≥30 mm, and radiographic other-organ invasions were risk factors for positive cytology in pancreatic cancer. This scoring system might be a useful indicator to perform staging laparoscopy to diagnose positive cytology.

Abstract Image

预测可切除和边缘可切除胰腺癌患者腹膜细胞学阳性的评分系统。
背景:本研究旨在评估预测腹膜细胞学阳性的因素,以确定胰腺癌分期腹腔镜检查的适应症:本研究旨在评估预测腹膜细胞学阳性的因素,从而确定胰腺癌分期腹腔镜检查的适应症:回顾性分析了430例因可切除和边缘可切除胰腺癌而接受胰腺切除术的患者:结果:430例患者中,36例细胞学检查呈阳性(8.4%)。细胞学阴性患者的中位生存时间为24.7个月,而细胞学阳性患者的中位生存时间为15.1个月(P = .004)。根据多变量分析,预测胰腺癌细胞学检查阳性的因素包括肿瘤位置(体部、尾部;OR 2.66;95% CI:1.21-5.85;p = .015)、肿瘤大小≥30 毫米(OR 2.95;95% CI:1.35-6.47;p = .007)和放射学其他器官侵犯(HR 2.79;95% CI:1.01-7.67;p = .047)。根据这些因素对患者进行 0 至 3 级评分。各评分的细胞学阳性率分别为:0分:2.9%;1分:6.7%;2分:18.3%;3分:36.8%:结论:肿瘤位置(体部或尾部)、肿瘤大小≥30 毫米和其他器官放射学侵犯是胰腺癌细胞学检查阳性的危险因素。该评分系统可能是进行分期腹腔镜检查诊断细胞学阳性的有用指标。
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来源期刊
Journal of Hepato‐Biliary‐Pancreatic Sciences
Journal of Hepato‐Biliary‐Pancreatic Sciences GASTROENTEROLOGY & HEPATOLOGY-SURGERY
自引率
10.00%
发文量
178
审稿时长
6-12 weeks
期刊介绍: The Journal of Hepato-Biliary-Pancreatic Sciences (JHBPS) is the leading peer-reviewed journal in the field of hepato-biliary-pancreatic sciences. JHBPS publishes articles dealing with clinical research as well as translational research on all aspects of this field. Coverage includes Original Article, Review Article, Images of Interest, Rapid Communication and an announcement section. Letters to the Editor and comments on the journal’s policies or content are also included. JHBPS welcomes submissions from surgeons, physicians, endoscopists, radiologists, oncologists, and pathologists.
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