Association of Overweight and Inflammatory Indicators with Breast Cancer: A Cross-Sectional Study in Chinese Women.

IF 2.5 4区医学 Q2 OBSTETRICS & GYNECOLOGY

International Journal of Women's Health Pub Date : 2024-05-06 eCollection Date: 2024-01-01 DOI:10.2147/IJWH.S428696

Juan-Min Zha, Mei Zhang, Tao Wang, Hua-Shan Li, Quan-Yao Ban, Mei Liu, Xue-Xue Jiang, Shi-Ying Guo, Jing Wang, Ya-Ru Zhou, Yu-Hong Liu, Wei-Qi He, Hong Xu

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引用次数: 0

Abstract

Objective: This cross-sectional study aimed to explore the association of overweight and inflammatory indicators with breast cancer risk in Chinese patients.

Methods: Weight, height, and peripheral blood inflammatory indicators, including white blood cell count (WBC), neutrophil count (NE), lymphocyte count (LY), platelet count (PLT) and the concentration of hypersensitivity C-reactive protein (hsCRP), were collected in 383 patients with benign breast lumps (non-cancer) and 358 patients with malignant breast tumors (cancer) at the First Affiliated Hospital of Soochow University, China, from March 2018 to July 2020. Body mass index (BMI), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) were determined according to the ratio equation. The correlations among overweight, inflammatory indicators, and the proportion of non-cancer or cancer cases were analyzed.

Results: BMI is associated with an increased breast cancer risk. Compared with non-cancer patients, the average WBC count, NE count, NLR, and level of hsCRP were significantly higher in cancer patients. The level of hsCRP was closely associated with the size of malignant breast tumors.

Conclusion: We conclude that overweight and high levels of hsCRP may serve as putative risk factors for malignant breast tumors in Chinese women.

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超重和炎症指标与乳腺癌的关系：中国女性的横断面研究

目的：本横断面研究旨在探讨中国患者超重和炎症指标与乳腺癌风险的关系：本横断面研究旨在探讨中国患者超重和炎症指标与乳腺癌风险的关系：方法：收集2018年3月至2020年7月苏州大学附属第一医院383例良性乳腺肿块（非癌症）患者和358例恶性乳腺肿瘤（癌症）患者的体重、身高和外周血炎症指标，包括白细胞计数（WBC）、中性粒细胞计数（NE）、淋巴细胞计数（LY）、血小板计数（PLT）和超敏C反应蛋白（hsCRP）浓度。根据比值方程测定体重指数（BMI）、中性粒细胞-淋巴细胞比值（NLR）、血小板-淋巴细胞比值（PLR）和全身免疫炎症指数（SII）。分析了超重、炎症指标、非癌症或癌症病例比例之间的相关性：结果：体重指数与乳腺癌风险增加有关。与非癌症患者相比，癌症患者的平均白细胞计数、NE计数、NLR和hsCRP水平显著升高。hsCRP 水平与恶性乳腺肿瘤的大小密切相关：结论：超重和高水平的 hsCRP 可能是中国女性罹患恶性乳腺肿瘤的潜在危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Women's Health OBSTETRICS & GYNECOLOGY-

CiteScore

3.70

自引率

0.00%

发文量

194

审稿时长

16 weeks

期刊介绍： International Journal of Women''s Health is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of women''s healthcare including gynecology, obstetrics, and breast cancer. Subject areas include: Chronic conditions including cancers of various organs specific and not specific to women Migraine, headaches, arthritis, osteoporosis Endocrine and autoimmune syndromes - asthma, multiple sclerosis, lupus, diabetes Sexual and reproductive health including fertility patterns and emerging technologies to address infertility Infectious disease with chronic sequelae including HIV/AIDS, HPV, PID, and other STDs Psychological and psychosocial conditions - depression across the life span, substance abuse, domestic violence Health maintenance among aging females - factors affecting the quality of life including physical, social and mental issues Avenues for health promotion and disease prevention across the life span Male vs female incidence comparisons for conditions that affect both genders.