Molecular probes for super-resolution imaging of drug dynamics

IF 15.2 1区医学 Q1 PHARMACOLOGY & PHARMACY

Advanced drug delivery reviews Pub Date : 2024-05-10 DOI:10.1016/j.addr.2024.115330

Hongbao Fang , Mengmeng Wang , Pengfan Wei , Qian Liu , Yan Su , Hongke Liu , Yuncong Chen , Zhi Su , Weijiang He

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引用次数: 0

Abstract

Super-resolution molecular probes (SRMPs) are essential tools for visualizing drug dynamics within cells, transcending the resolution limits of conventional microscopy. In this review, we provide an overview of the principles and design strategies of SRMPs, emphasizing their role in accurately tracking drug molecules. By illuminating the intricate processes of drug distribution, diffusion, uptake, and metabolism at a subcellular and molecular level, SRMPs offer crucial insights into therapeutic interventions. Additionally, we explore the practical applications of super-resolution imaging in disease treatment, highlighting the significance of SRMPs in advancing our understanding of drug action. Finally, we discuss future perspectives, envisioning potential advancements and innovations in this field. Overall, this review serves to inform and practitioners about the utility of SRMPs in driving innovation and progress in pharmacology, providing valuable insights for drug development and optimization.

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用于药物动态超分辨率成像的分子探针。

超分辨率分子探针（SRMP）是观察细胞内药物动态的重要工具，它超越了传统显微镜的分辨率限制。在这篇综述中，我们将概述超分辨率分子探针的原理和设计策略，强调它们在精确追踪药物分子方面的作用。通过阐明药物在亚细胞和分子水平上分布、扩散、吸收和代谢的复杂过程，SRMP 为治疗干预提供了至关重要的见解。此外，我们还探讨了超分辨率成像在疾病治疗中的实际应用，强调了 SRMP 在促进我们了解药物作用方面的重要意义。最后，我们讨论了未来前景，展望了该领域的潜在进步和创新。总之，这篇综述旨在让从业人员了解 SRMP 在推动药理学创新和进步方面的作用，为药物开发和优化提供有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced drug delivery reviews 医学-药学

CiteScore

28.10

自引率

5.00%

发文量

294

审稿时长

15.1 weeks

期刊介绍： The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery. In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.