The risk for ophthalmological conditions in ulcerative colitis: A population-based case–control study. Is silica dust-exposure associated with inflammatory eye disease?

IF 3 3区医学 Q1 OPHTHALMOLOGY

Acta Ophthalmologica Pub Date : 2024-05-13 DOI:10.1111/aos.16708

Karim Makdoumi, Lucyn Ayoub, Ing-Liss Bryngelsson, Pål Graff, Pernilla Wiebert, Per Vihlborg

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Abstract

Purpose

To study the risk for eye diseases in individuals with Ulcerative Colitis (UC), and to assess whether silica dust-exposure could contribute to the development of inflammatory eye diseases.

Methods

A case–control study was conducted using a patient register processed by the National Board of Health and Welfare (NBHW) and Statistics Sweden. Cases were diagnosed with UC between 2007 and 2016. Matching was done with two random controls having the same age, sex and county of residence, without a systemic inflammatory disease. Using a job-exposure matrix, cases and controls were assessed for work-related silica dust exposure. The risk for eye disease was estimated by Cox regression analysis with calculation of Hazard Ratio (HR).

Results

A total of 58 989 individuals were included, comprising 19 663 cases and 39 326 controls. The sex distribution was similar. Overall, individuals with UC had an increased risk for eye disease, specified in ICD 10 chapter VII (H00-H59) with HR 1.25 (CI 1.20–1.32). The highest HR on block-level for cases was 1.52 (CI 1.36–1.70), (H15-H22), which includes episcleritis, keratitis and anterior uveitis. The risk for ocular disease was higher in silica dust-exposed than non-exposed with a HR of 1.44 (CI 1.16–1.78) and 1.25 (CI 1.19–1.31), respectively. Among cases, the risk for iridocyclitis (H20) was further elevated by silica dust exposure, with HR of 3.84 (CI 1.64–8.97) in exposed compared to 1.94 (1.57–2.41) in non-exposed.

Conclusion

UC is associated with an increased risk for eye diseases, including inflammatory conditions. Our findings highlight that silica dust-exposure may be of importance in the pathogenesis of uveitis.

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溃疡性结肠炎患者罹患眼科疾病的风险：基于人群的病例对照研究。矽尘暴露与炎症性眼病有关吗？

目的：研究溃疡性结肠炎（UC）患者罹患眼部疾病的风险，并评估二氧化硅粉尘暴露是否会导致炎症性眼部疾病的发生：方法：利用瑞典国家卫生与福利委员会（NBHW）和瑞典统计局处理的患者登记册开展了一项病例对照研究。病例均在 2007 年至 2016 年期间被确诊为 UC。随机抽取两名年龄、性别和居住地相同且未患系统性炎症疾病的对照者进行配对。利用工作暴露矩阵，对病例和对照组进行了与工作相关的矽尘暴露评估。通过考克斯回归分析估算眼部疾病的风险，并计算危险比（HR）：结果：共纳入 58 989 人，包括 19 663 例病例和 39 326 例对照。性别分布相似。总体而言，UC 患者罹患 ICD 10 第七章（H00-H59）规定的眼部疾病的风险增加，HR 为 1.25（CI 为 1.20-1.32）。病例组的最高 HR 为 1.52（CI 1.36-1.70）（H15-H22），其中包括上巩膜炎、角膜炎和前葡萄膜炎。接触过二氧化硅粉尘的人比未接触过二氧化硅粉尘的人患眼部疾病的风险更高，HR 分别为 1.44 (CI 1.16-1.78) 和 1.25 (CI 1.19-1.31)。在病例中，罹患虹膜睫状体炎（H20）的风险因暴露于二氧化硅粉尘而进一步升高，暴露者的 HR 为 3.84（CI 1.64-8.97），而非暴露者的 HR 为 1.94（1.57-2.41）：UC与眼部疾病（包括炎症）的风险增加有关。我们的研究结果表明，暴露于二氧化硅粉尘可能是葡萄膜炎发病机制中的一个重要因素。

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来源期刊

Acta Ophthalmologica 医学-眼科学

CiteScore

7.60

自引率

5.90%

发文量

433

审稿时长

6 months

期刊介绍： Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.