The association between the human papillomavirus (HPV) and the diagnosis of bladder cancer: systematic review and meta-analysis

Actas urologicas espanolas Pub Date : 2024-07-01 DOI:10.1016/j.acuroe.2024.05.002

I.J. Otero-Muriel , S. Jiménez Giraldo , H.A. García-Perdomo

{"title":"The association between the human papillomavirus (HPV) and the diagnosis of bladder cancer: systematic review and meta-analysis","authors":"I.J. Otero-Muriel , S. Jiménez Giraldo , H.A. García-Perdomo","doi":"10.1016/j.acuroe.2024.05.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Bladder cancer (BC) is the seventh most common cancer worldwide. Not every infection ends as cancer, although the HPV-induced carcinogenesis is a complex process consequence of inflammation. To determine the association between human papillomavirus (HPV) and the diagnosis of bladder cancer.</p></div><div><h3>Methods</h3><p>We carried out a systematic review according to Cochrane and PRISMA recommendations. We searched in EMBASE, Medline (Ovid), and The Cochrane Central Register of Controlled Trials (CENTRAL), from inception to nowadays. We included case-control studies. The risk of bias assessment was performed based on QUADAS2. We performed a random effect Meta-analysis.</p></div><div><h3>Results</h3><p>We included 14 studies in qualitative and quantitative analysis. There was mainly a low risk of bias. We finally found a strong association between the presence of HPV and bladder cancer diagnosis (OR 4.18 95%CI 2.63–6.66; I2 = 40%).</p></div><div><h3>Conclusions</h3><p>HPV is currently associated with the diagnosis of bladder cancer.</p></div>","PeriodicalId":94291,"journal":{"name":"Actas urologicas espanolas","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Actas urologicas espanolas","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2173578624000623","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Bladder cancer (BC) is the seventh most common cancer worldwide. Not every infection ends as cancer, although the HPV-induced carcinogenesis is a complex process consequence of inflammation. To determine the association between human papillomavirus (HPV) and the diagnosis of bladder cancer.

Methods

We carried out a systematic review according to Cochrane and PRISMA recommendations. We searched in EMBASE, Medline (Ovid), and The Cochrane Central Register of Controlled Trials (CENTRAL), from inception to nowadays. We included case-control studies. The risk of bias assessment was performed based on QUADAS2. We performed a random effect Meta-analysis.

Results

We included 14 studies in qualitative and quantitative analysis. There was mainly a low risk of bias. We finally found a strong association between the presence of HPV and bladder cancer diagnosis (OR 4.18 95%CI 2.63–6.66; I2 = 40%).

Conclusions

HPV is currently associated with the diagnosis of bladder cancer.

Abstract Image

查看原文本刊更多论文

人类乳头瘤病毒（hpv）与膀胱癌诊断之间的关联：系统回顾与荟萃分析。

背景：膀胱癌（BC）是全球第七大常见癌症：膀胱癌（BC）是全球第七大常见癌症。尽管人乳头瘤病毒（HPV）诱发的癌变是一个复杂的炎症过程，但并非所有感染都会导致癌症。为了确定人类乳头瘤病毒（HPV）与膀胱癌诊断之间的关联：方法：我们根据 Cochrane 和 PRISMA 建议进行了系统性回顾。我们检索了 EMBASE、Medline (Ovid) 和 Cochrane 对照试验中央注册中心 (CENTRAL)，检索时间从开始到现在。我们纳入了病例对照研究。偏倚风险评估基于 QUADAS2 进行。我们进行了随机效应 Meta 分析：我们对 14 项研究进行了定性和定量分析。主要存在低偏倚风险。我们最终发现，HPV 的存在与膀胱癌诊断之间存在密切联系（OR 4.18 95%CI 2.63 至 6.66；I2 = 40%）：目前，HPV 与膀胱癌的诊断有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Actas urologicas espanolas

自引率

0.00%

发文量