A review concerning the breast cancer-related tumour microenvironment

IF 5.5 2区医学 Q1 HEMATOLOGY

Critical reviews in oncology/hematology Pub Date : 2024-05-10 DOI:10.1016/j.critrevonc.2024.104389

Oscar Hernán Rodríguez-Bejarano , Carlos Parra-López , Manuel Alfonso Patarroyo

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Abstract

Breast cancer (BC) is currently the most common malignant tumour in women and one of the leading causes of their death around the world. New and increasingly personalised diagnostic and therapeutic tools have been introduced over the last few decades, along with significant advances regarding the study and knowledge related to BC. The tumour microenvironment (TME) refers to the tumour cell-associated cellular and molecular environment which can influence conditions affecting tumour development and progression. The TME is composed of immune cells, stromal cells, extracellular matrix (ECM) and signalling molecules secreted by these different cell types. Ever deeper understanding of TME composition changes during tumour development and progression will enable new and more innovative therapeutic strategies to become developed for targeting tumours during specific stages of its evolution. This review summarises the role of BC-related TME components and their influence on tumour progression and the development of resistance to therapy. In addition, an account on the modifications in BC-related TME components associated with therapy is given, and the completed or ongoing clinical trials related to this topic are presented.

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乳腺癌相关肿瘤微环境综述。

乳腺癌（BC）是目前全球女性最常见的恶性肿瘤，也是导致女性死亡的主要原因之一。过去几十年来，随着乳腺癌相关研究和知识的长足进步，新的、越来越个性化的诊断和治疗工具不断问世。肿瘤微环境（TME）是指与肿瘤细胞相关的细胞和分子环境，可影响肿瘤发生和发展的条件。肿瘤微环境由免疫细胞、基质细胞、细胞外基质（ECM）和这些不同类型细胞分泌的信号分子组成。加深对肿瘤发生和发展过程中TME组成变化的了解，将有助于开发新的、更具创新性的治疗策略，在肿瘤演变的特定阶段对其进行靶向治疗。本综述总结了与 BC 相关的 TME 成分的作用及其对肿瘤进展和耐药性发展的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical reviews in oncology/hematology 医学-血液学

CiteScore

11.00

自引率

3.20%

发文量

213

审稿时长

55 days

期刊介绍： Critical Reviews in Oncology/Hematology publishes scholarly, critical reviews in all fields of oncology and hematology written by experts from around the world. Critical Reviews in Oncology/Hematology is the Official Journal of the European School of Oncology (ESO) and the International Society of Liquid Biopsy.