Alzheimer's disease: insights into pathology, molecular mechanisms, and therapy.

IF 13.6 1区 生物学 Q1 CELL BIOLOGY
Qiuyang Zheng, Xin Wang
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引用次数: 0

Abstract

Alzheimer's disease (AD), the leading cause of dementia, is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. This condition casts a significant shadow on global health due to its complex and multifactorial nature. In addition to genetic predispositions, the development of AD is influenced by a myriad of risk factors, including aging, systemic inflammation, chronic health conditions, lifestyle and environmental exposures. Recent advancements in understanding the complex pathophysiology of AD are paving the way for enhanced diagnostic techniques, improved risk assessment, and potentially effective prevention strategies. These discoveries are crucial in the quest to unravel the complexities of AD, offering a beacon of hope for improved management and treatment options for the millions affected by this debilitating disease.

阿尔茨海默病:对病理学、分子机制和治疗的见解。
阿尔茨海默病(AD)是导致痴呆症的主要原因,其特征是淀粉样蛋白斑块和神经纤维缠结在大脑中的积累。由于其复杂性和多因素性,这种疾病给全球健康蒙上了巨大的阴影。除了遗传易感性外,注意力缺失症的发生还受到无数风险因素的影响,包括衰老、全身炎症、慢性健康状况、生活方式和环境暴露。最近,人们在了解注意力缺失症复杂的病理生理学方面取得了进展,为加强诊断技术、改进风险评估和制定潜在的有效预防策略铺平了道路。这些发现对于揭开注意力缺失症的复杂面纱至关重要,为数百万受到这种使人衰弱的疾病影响的人提供了改善管理和治疗方案的希望灯塔。
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来源期刊
Protein & Cell
Protein & Cell CELL BIOLOGY-
CiteScore
24.00
自引率
0.90%
发文量
1029
审稿时长
6-12 weeks
期刊介绍: Protein & Cell is a monthly, peer-reviewed, open-access journal focusing on multidisciplinary aspects of biology and biomedicine, with a primary emphasis on protein and cell research. It publishes original research articles, reviews, and commentaries across various fields including biochemistry, biophysics, cell biology, genetics, immunology, microbiology, molecular biology, neuroscience, oncology, protein science, structural biology, and translational medicine. The journal also features content on research policies, funding trends in China, and serves as a platform for academic exchange among life science researchers.
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