Lectibodies as antivirals

IF 4.5 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Ian Carlosalberto Santisteban Celis , Nobuyuki Matoba
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引用次数: 0

Abstract

Growing concerns regarding the emergence of highly transmissible viral diseases highlight the urgent need to expand the repertoire of antiviral therapeutics. For this reason, new strategies for neutralizing and inhibiting these viruses are necessary. A promising approach involves targeting the glycans present on the surfaces of enveloped viruses. Lectins, known for their ability to recognize specific carbohydrate molecules, offer the potential for glycan-targeted antiviral strategies. Indeed, numerous studies have reported the antiviral effects of various lectins of both endogenous and exogenous origins. However, many lectins in their natural forms, are not suitable for use as antiviral therapeutics due to toxicity, other unfavorable pharmacological effects, and/or unreliable manufacturing sources. Therefore, improvements are crucial for employing lectins as effective antiviral therapeutics. A novel approach to enhance lectins’ suitability as pharmaceuticals could be the generation of recombinant lectin-Fc fusion proteins, termed “lectibodies.” In this review, we discuss the scientific rationale behind lectin-based antiviral strategies and explore how lectibodies could facilitate the development of new antiviral therapeutics. We will also share our perspective on the potential of these molecules to transcend their potential use as antiviral agents.

作为抗病毒药物的抗体。
人们对高传播病毒性疾病的出现日益关注,这凸显了扩大抗病毒疗法范围的迫切需要。因此,有必要采用新的策略来中和并抑制这些病毒。一种很有前景的方法是以包膜病毒表面的聚糖为靶标。凝集素以其识别特定碳水化合物分子的能力而闻名,为以聚糖为靶点的抗病毒策略提供了可能性。事实上,许多研究都报道了各种内源性和外源性凝集素的抗病毒作用。然而,由于毒性、其他不利的药理作用和/或不可靠的制造来源,许多天然形式的凝集素并不适合用作抗病毒疗法。因此,要将凝集素用作有效的抗病毒疗法,必须对其进行改进。提高凝集素作为药物的适用性的一种新方法可能是生成重组凝集素-Fc融合蛋白,即 "凝集体"。在这篇综述中,我们将讨论基于凝集素的抗病毒策略背后的科学原理,并探讨凝集体如何促进新型抗病毒疗法的开发。我们还将分享我们对这些分子作为抗病毒药物的潜在用途的看法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Antiviral research
Antiviral research 医学-病毒学
CiteScore
17.10
自引率
3.90%
发文量
157
审稿时长
34 days
期刊介绍: Antiviral Research is a journal that focuses on various aspects of controlling viral infections in both humans and animals. It is a platform for publishing research reports, short communications, review articles, and commentaries. The journal covers a wide range of topics including antiviral drugs, antibodies, and host-response modifiers. These topics encompass their synthesis, in vitro and in vivo testing, as well as mechanisms of action. Additionally, the journal also publishes studies on the development of new or improved vaccines against viral infections in humans. It delves into assessing the safety of drugs and vaccines, tracking the evolution of drug or vaccine-resistant viruses, and developing effective countermeasures. Another area of interest includes the identification and validation of new drug targets. The journal further explores laboratory animal models of viral diseases, investigates the pathogenesis of viral diseases, and examines the mechanisms by which viruses avoid host immune responses.
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